# US 11,298,548 B2 · Dual-electrogram based control of cardiac resynchronization therapy > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,298,548 B2 - Document ID: US11298548B2 - Status: Granted - Kind: B2 - Application number: 16/742,443 - Filed: 2020-01-14 - Published: 2020-07-23 - Granted: 2022-04-12 - Earliest claimed: 2019-01-23 - Assignees: Medtronic, Inc. - Applicants: Medtronic, Inc. - Inventors: Eduardo N. Warman - Web page: https://patentgrep.com/patent/US11298548B2 ## CPC - A61N 1/36843: {Bi-ventricular stimulation} - A61N 1/056: {Transvascular endocardial electrode systems} - A61N 1/365: controlled by a physiological parameter, e.g. heart potential {(evoked response A61N1/371)} - A61N 1/3682: {with a variable atrioventricular delay} - A61N 1/3702: {Physiological parameters (A61N1/365 takes precedence; evoked response A61N1/371)} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract In some examples, controlling delivery of CRT includes controlling an implantable medical device to deliver ventricular pacing according to a sequence of different values of a CRT parameter, and acquiring first and second electrograms from respective first and second electrode vectors. For each value of the CRT parameter, a value of a metric of comparison of a first activation interval between occurrences of a first fiducial of a cardiac cycle and a second fiducial of the cardiac cycle detected in the first electrogram to a second activation interval between occurrences of the first fiducial and the second fiducial detected in the second electrogram may be determined. A target value of the metric of comparison may be identified and an updated value of the CRT parameter determined based on the target value. The system then may control the IMD to deliver ventricular pacing at the updated value of the CRT parameter. ## Claims ### Claim 1 A method for controlling delivery of cardiac resynchronization therapy (CRT) using an implantable medical device configured for implantation within a patient, the method comprising, by processing circuitry of a medical device system comprising the implantable medical device: controlling the implantable medical device to deliver ventricular pacing to a heart of the patient according to a sequence of different values of a CRT parameter; acquiring, during the delivery of ventricular pacing according to the sequence, a first electrogram and a second electrogram from respective ones of a first vector formed from a plurality of electrodes of the medical device system and a second vector formed from the plurality of electrodes; determining, for each of the different values of the CRT parameter, a first activation interval between an occurrence of a first fiducial of a cardiac cycle and a second fiducial of the cardiac cycle detected in the first electrogram and a second activation interval between the occurrence of the first fiducial of the cardiac cycle and the second fiducial of the cardiac cycle detected in the second electrogram; determining, for each of the different values of the CRT parameter, a value of a metric of comparison of the first activation interval to the second activation interval, wherein the metric of comparison comprises one or more of a ratio of the first and second activation intervals and a time difference between the first and second activation intervals; determining an updated value of the CRT parameter using the metric of comparison and a target value; and controlling the implantable medical device to deliver the ventricular pacing with the updated value of the CRT parameter. ### Claim 2 (depends on 1) The method of claim 1, wherein the target value corresponds to fusion occurring between left ventricular activation and right ventricular activation. ### Claim 3 (depends on 1) The method of claim 1, wherein the time difference is a time difference between the occurrence of the second fiducial of the cardiac cycle detected in the first electrogram and the occurrence of the second fiducial of the cardiac cycle detected in the second electrogram, and wherein the method further comprises identifying the target value of the metric of comparison comprises identifying a minimum value of the time difference. ### Claim 4 (depends on 1) The method of claim 1, wherein the target value comprises one of a minimum value of the time difference or a value of the ratio that is closest to a value of 1. ### Claim 5 (depends on 1) The method of claim 1, wherein the target value comprises one of a value of the one or more of the ratio or the time difference that is equal to or less than a threshold value or a value of the ratio that is within a threshold distance from a value of 1. ### Claim 6 (depends on 1) The method of claim 1, wherein the CRT parameter is an A-V delay. ### Claim 7 (depends on 1) The method of claim 1, wherein the CRT parameter is a V-V delay. ### Claim 8 (depends on 1) The method of claim 1, wherein the CRT parameter comprises an atrioventricular (A-V) delay, wherein controlling the implantable medical device to deliver ventricular pacing according to a sequence of different values of a CRT parameter comprises controlling the implantable medical device to deliver left-ventricular pacing according to a sequence of different values of A-V delay, and wherein controlling the implantable medical device to deliver the ventricular pacing with the updated value of the CRT parameter comprises controlling the implantable medical device to deliver left ventricular fusion pacing. ### Claim 9 (depends on 1) The method of claim 1, wherein controlling the implantable medical device to deliver the ventricular pacing at the updated value of the CRT parameter comprises controlling the implantable medical device to deliver the ventricular pacing at the value of the CRT parameter that resulted in the target value. ### Claim 10 (depends on 1) The method of claim 1, wherein the first fiducial corresponds to a time of delivery by the implantable medical device of a ventricular pacing pulse for the cardiac cycle. ### Claim 11 (depends on 1) The method of claim 1, wherein the second fiducial corresponds to one of onset of a paced ventricular activation, a maximum dv/dt, a detected R-wave, and a maximum amplitude of the first electrogram and the second electrogram. ### Claim 12 (depends on 1) The method of claim 1, wherein the first vector and the second vector are orthogonal to one another. ### Claim 13 (depends on 1) The method of claim 1, wherein the first vector and the second vector each include a common electrode of the plurality of electrodes. ### Claim 14 (depends on 1) The method of claim 1, wherein the implantable medical device comprises an implantable CRT device comprising the processing circuitry, wherein the implantable CRT device is coupled to the plurality of electrodes by one or more implantable leads configured for implantation within the patient, each of the one or more implantable leads comprising one or more electrodes of the plurality of electrodes. ### Claim 15 (depends on 14) The method of claim 14, wherein the implantable CRT device comprises a housing comprising an electrode of the plurality of electrodes and the one or more implantable leads comprises a first lead configured for implantation within a right ventricle of the heart and a second lead configured for implantation within a left ventricle of the heart, wherein the first vector is between the housing and at least one electrode of the one or more electrodes on the first lead, and wherein the second vector is between at least one electrode of the one or more electrodes on the first lead and at least one electrode of the one or more electrodes on the second lead. ### Claim 16 (depends on 1) The method of claim 1, wherein the medical device system further comprises a memory and wherein controlling the implantable medical device to deliver the ventricular pacing to the heart of the patient according to the sequence of different values of the CRT parameter comprises controlling the implantable medical device to deliver the ventricular pacing to the heart of the patient according to the sequence of different values of the CRT parameter based on a determination to update one or more CRT parameters, the one or more CRT parameters comprising the CRT parameter, the method further comprising storing the updated CRT parameter in the memory as at least one updated value of the one or more CRT parameters. ### Claim 17 (depends on 1) The method of claim 1, wherein determining an updated value of the CRT parameter using the metric of comparison and a target value comprises determining the updated value of the CRT parameter based upon a comparison of the metric of comparison to the target value. ### Claim 18 (depends on 17) The method according to claim 17, wherein determining the updated value of the CRT parameter based upon a comparison of the metric of comparison to the target value comprises determining which one of the different values of the CRT parameter is closest to the target value and selecting the value of the CRT parameter that is closest to the target value as the updated value of the CRT parameter. ### Claim 19 A system for controlling delivery of cardiac resynchronization therapy (CRT) to a patient, the system comprising: a plurality of electrodes; an implantable medical device configured to deliver ventricular pacing to the patient; sensing circuitry configured to sense electrical activity of the heart via the plurality of electrodes; and processing circuitry configured to: control the implantable medical device to deliver ventricular pacing according to a sequence of different values of a CRT parameter; acquire, via the sensing circuitry and during the delivery of ventricular pacing according to the sequence, a first electrogram and a second electrogram from respective ones of a first vector formed from the plurality of electrodes and a second vector formed from the plurality of electrodes; determine, for each of the different values of the CRT parameter, a first activation interval between an occurrence of a first fiducial of a cardiac cycle and a second fiducial of a cardiac cycle detected in the first electrogram and a second activation interval between the occurrence of the first fiducial of the cardiac cycle and the second fiducial of a cardiac cycle detected in the second electrogram; determine, for each of the different values of the CRT parameter, a value of a metric of comparison of the first activation interval to the second activation interval, wherein the metric of comparison comprises one or more of a ratio of the first and second activation intervals and a time difference between the first and second activation intervals; determine an updated value of the CRT parameter using the metric of comparison; and control the implantable medical device to deliver the ventricular pacing with the updated value of the CRT parameter. ### Claim 20 (depends on 19) A system according to claim 19, wherein the processing circuitry is configured to determine the updated value of the CRT parameter based upon a comparison of the metric of comparison to a defined target value. ### Claim 21 (depends on 20) A system according to claim 20, wherein the processing circuitry is further configured to determine which one of the different values of the CRT parameter is closest to the target value and select the value of the CRT parameter that is closest to the target value as the updated value of the CRT parameter. ### Claim 22 (depends on 20) The system of claim 20, wherein the target value corresponds to fusion occurring between left ventricular activation and right ventricular activation. ### Claim 23 (depends on 20) The system of claim 20, wherein the time difference is a time difference between the occurrence of the second fiducial of the cardiac cycle detected in the first electrogram and the occurrence of the second fiducial of the cardiac cycle detected in the second electrogram, and wherein the processing circuitry is further configured to identify the target value of the metric of comparison by identifying a minimum value of the time difference. ### Claim 24 (depends on 20) The system of claim 20, wherein the target value comprises one of a minimum value of the time difference and a value of the ratio that is closest to a value of 1. ### Claim 25 (depends on 20) The system of claim 20, wherein the target value comprises one of a value of the one or more of the ratio and the time difference that is equal to or less than a threshold value or a value of the ratio that is within a threshold distance from a value of 1. ### Claim 26 (depends on 19) The system of claim 19, wherein the CRT parameter is an A-V delay. ### Claim 27 (depends on 19) The system of claim 19, wherein the CRT parameter is a V-V delay. ### Claim 28 (depends on 19) The system of claim 19, wherein the CRT parameter comprises an atrioventricular (A-V) delay, wherein controlling the implantable medical device to deliver ventricular pacing according to a sequence of different values of a CRT parameter comprises controlling the implantable medical device to deliver ventricular pacing according to a sequence of different values of the A-V delay, and wherein controlling the implantable medical device to deliver the ventricular pacing with the updated value of the CRT parameter comprises controlling the implantable medical device to deliver left ventricular fusion pacing. ### Claim 29 (depends on 20) The system of claim 20, wherein the processing circuitry is configured to control the implantable medical device to deliver the ventricular pacing with the updated value of the CRT parameter by at least controlling the implantable medical device to deliver the ventricular pacing at the value of the CRT parameter that resulted in the target value. ### Claim 30 (depends on 19) The system of claim 19, wherein the first fiducial corresponds to a time of delivery by the implantable medical device of a ventricular pacing pulse for the cardiac cycle. ### Claim 31 (depends on 19) The system of claim 19, wherein the second fiducial corresponds to one of onset of a paced ventricular activation, a maximum dv/dt, a detected R-wave, and a maximum amplitude of the first electrogram and the second electrogram. ### Claim 32 (depends on 19) The system of claim 19, wherein the first vector and the second vector are orthogonal to one another. ### Claim 33 (depends on 19) The system of claim 19, wherein the first vector and the second vector each include a common electrode of the plurality of electrodes. ### Claim 34 (depends on 19) The system of claim 19, wherein the implantable medical device comprises an implantable CRT device comprising the processing circuitry, the system further comprising one or more implantable leads configured for implantation within the patient, wherein the implantable CRT device is coupled to the plurality of electrodes by the one or more implantable leads, each of the one or more implantable leads comprising one or more electrodes of the plurality of electrodes. ### Claim 35 (depends on 34) The system of claim 34, wherein the implantable CRT device further comprises a housing comprising an electrode of the plurality of electrodes and the one or more implantable leads comprises a first lead configured for implantation within a right ventricle of the heart and a second lead configured for implantation within a left ventricle of the heart, wherein the first vector is between the housing and at least one electrode of the one or more electrodes on the first lead, and wherein the second vector is between at least one electrode of the one or more electrodes on the first lead and at least one electrode of the one or more electrodes on the second lead. ### Claim 36 (depends on 19) The system of claim 19, wherein the medical device system further comprises a memory and the processing circuitry is configured to control the implantable medical device to deliver the ventricular pacing to the heart of the patient according to the sequence of different values of the CRT parameter by at least controlling the implantable medical device to deliver the ventricular pacing to the heart of the patient according to the sequence of different values of the CRT parameter based on a determination to update one or more CRT parameters, the one or more CRT parameters comprising the CRT parameter, and wherein the processing circuitry is further configured to store the updated CRT parameter in the memory as at least one updated value of the one or more CRT parameters. ### Claim 37 A system for controlling delivery of cardiac resynchronization therapy (CRT) to a patient, the system comprising: a plurality of electrodes; an implantable medical device configured to deliver ventricular pacing to the patient; sensing circuitry configured to sense electrical activity of the heart via the plurality of electrodes; and processing circuitry configured to: control the implantable medical device to deliver ventricular pacing according to a sequence of different values of an A-V delay; acquire, via the sensing circuitry and during the delivery of ventricular pacing according to the sequence, a first electrogram and a second electrogram from respective ones of a first vector formed from the plurality of electrodes and a second vector formed from the plurality of electrodes; determine, for each of the different values of the A-V delay, a first activation interval between an occurrence of a first fiducial of a cardiac cycle and a second fiducial of the cardiac cycle detected in the first electrogram and a second activation interval between the occurrence of the first fiducial of the cardiac cycle and the second fiducial of the cardiac cycle detected in the second electrogram; determine, for each of the different values of the A-V delay, one or more of a ratio of the first activation interval and the second activation interval and a time difference between the first activation interval and the second activation interval; identify one or more of a minimum value of the time difference and a value of the ratio that is closest to a value of 1; determine an updated value of the A-V delay based on the identified one or more of the minimum value of the time delay and the value of the ratio that is closest to a value of 1; and control the implantable medical device to deliver the ventricular pacing with the updated value of the A-V delay to provide CRT. ### Claim 38 A non-transitory computer-readable medium storing instructions for causing processing circuitry to perform a method for controlling delivery of cardiac resynchronization therapy (CRT) using a medical device system, the medical device system comprising the processing circuitry, a plurality of electrodes, an implantable medical device configured for implantation within a patient and comprising at least one electrode of the plurality of electrodes, and sensing circuitry configured to sense electrical activity of the heart via the plurality of electrodes, the method comprising: controlling the implantable medical device to deliver ventricular pacing according to a sequence of different values of a CRT parameter; acquiring, during the delivery of ventricular pacing according to the sequence, a first electrogram and a second electrogram from respective ones of a first vector formed from the plurality of electrodes and a second vector formed from the plurality of electrodes; determining, for each of the different values of the CRT parameter, a first activation interval between an occurrence of a first fiducial of a cardiac cycle and a second fiducial of the cardiac cycle determined in the first electrogram and a second activation interval between the occurrence of the first fiducial of the cardiac cycle and the second fiducial of the cardiac cycle determined in the second electrogram; determining, for each of the different values of the CRT parameter, a value of a metric of comparison of the first activation interval to the second activation interval; identifying a target value of the metric of comparison of the first activation interval to the second activation interval; determining an updated value of the CRT parameter based on the identified target value; and controlling the implantable medical device to deliver the ventricular pacing at the updated value of the CRT parameter to provide CRT. ### Claim 39 (depends on 38) The non-transitory computer-readable medium of claim 38, wherein the metric of comparison comprises one or more of a ratio of the first activation interval to the second activation interval and a time difference between the first activation interval and the second activation interval. ### Claim 40 (depends on 39) The non-transitory computer-readable medium of claim 39, wherein the time difference is a time difference between the occurrence of the second fiducial of the cardiac cycle detected in the first electrogram and the occurrence of the second fiducial of the cardiac cycle detected in the second electrogram, and wherein identifying the target value of the metric of comparison comprises identifying a minimum value of the time difference. ### Claim 41 (depends on 39) The non-transitory computer-readable medium of claim 39, wherein the target value comprises one of a minimum value of the time difference and a value of the ratio that is closest to a value of 1. ### Claim 42 (depends on 39) The non-transitory computer-readable medium of claim 39, wherein the target value comprises one of a value of the one or more of the ratio and the time difference that is equal to or less than a threshold value or a value of the ratio that is within a threshold distance from a value of 1. ### Claim 43 (depends on 38, 39, 40, 41, 42) The non-transitory computer-readable medium of any of claims 38-42, wherein the first vector and the second vector are orthogonal to one another.