# US 11,298,541 B2 · Method and apparatus for improving cognitive performance

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- Number: US 11,298,541 B2
- Document ID: US11298541B2
- Status: Granted
- Kind: B2
- Application number: 16/569,205
- Filed: 2019-09-12
- Published: 2020-01-02
- Granted: 2022-04-12
- Earliest claimed: 2015-01-24
- Assignees: The Trustees of the University of Pennsylvania
- Applicants: The Trustees of the University of Pennsylvania
- Inventors: Michael Kahana; Daniel S. Rizzuto
- Web page: https://patentgrep.com/patent/US11298541B2

## CPC

- A61N 1/36082: {Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease}
- A61B 5/383: Somatosensory stimuli, e.g. electric stimulation
- A61N 1/0531: {Brain cortex electrodes}
- A61N 1/36064: {Epilepsy}
- A61N 1/36067: {Movement disorders, e.g. tremor or Parkinson disease (stimulating motor muscle A61N1/36003)}
- A61N 1/36135: {using physiological parameters}
- G16H 20/40: relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
- A61N 1/0534: {Electrodes for deep brain stimulation}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA

## Abstract

A method for delivering electrical stimulation to alter a cognitive state of a user, the method comprising: monitoring a brain signal from the user via one or more intracranial electrodes implanted in the brain of the user while the user is presented with a stimulus; comparing the brain signal to a testing phase biomarker, wherein the testing phase biomarker is derived from a cognitive test performed on a contributor during a testing phase; delivering electrical stimulation to a brain of the user based on the comparing step to steer the brain of the user towards a high performance cognitive state.

## Claims

### Claim 1

A method for delivering stimulation to alter a cognitive state of a user, the method comprising:
at an electrical stimulation device:
monitoring a brain signal from the user;
evaluating the cognitive state of the user by comparing the brain signal of the user with a testing phase biomarker, wherein the testing phase biomarker is derived from a cognitive test performed on a contributor during a testing phase; and
delivering stimulation to a brain of the user based on the evaluating step to steer the brain of the user towards high performance cognitive state;
wherein the testing phase biomarker is a representation of electrophysiological data and indicative of a high performance cognitive state of the user as determined based on a cognitive test performed on the contributor.

### Claim 2 (depends on 1)

The method of claim 1, wherein the contributor is the user.

### Claim 3 (depends on 1)

The method of claim 1, wherein the contributor is a plurality of contributors.

### Claim 4 (depends on 1)

The method of claim 1, wherein the contributor is different than the user.

### Claim 5 (depends on 1)

The method of claim 1, further comprising:
updating the testing phase biomarker based on the brain signal of the user and a response of the user to the stimulus.

### Claim 6 (depends on 1)

The method of claim 1, wherein electrical stimulation is delivered to a single subfield of a hippocampus.

### Claim 7 (depends on 1)

The method of claim 1, wherein electrical stimulation is delivered to multiple regions of the brain of the user.

### Claim 8 (depends on 1)

The method of claim 1, wherein comparing the brain signal to the testing phase biomarker includes comparing the brain signal to a biomarker representative value generated by applying a dimensionality reduction algorithm to the testing phase biomarker.

### Claim 9 (depends on 1)

The method of claim 1, wherein stimulation delivered to a brain of the user is based on predetermined stimulation optimization parameters derived before the monitoring step and configured to steer the brain of the user towards high performance cognitive state.

### Claim 10 (depends on 1)

A system for delivering electrical stimulation to alter a cognitive state of a user according to the method of claim 1.

### Claim 11 (depends on 1)

A non-transitory computer readable storage medium having stored thereon computer executable instructions which, when executed by a processor, perform the method of claim 1.