# US 11,298,502 B2 · Non-pharmaceutical methods of mitigating addiction withdrawal symptoms > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,298,502 B2 - Document ID: US11298502B2 - Status: Granted - Kind: B2 - Application number: 16/459,318 - Filed: 2019-07-01 - Published: 2019-10-24 - Granted: 2022-04-12 - Earliest claimed: 2015-11-23 - Assignees: Sana Health, Inc. - Applicants: Sana Health, Inc. - Inventors: Richard Hanbury - Web page: https://patentgrep.com/patent/US11298502B2 ## CPC - A61H 23/02: with electric or magnetic drive - A61M 21/02: for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia (for massage A61H; electrotherapy A61N, e.g. applying alternating or intermittent electric currents for producing anaesthesia A61N1/36021) - A61B 5/6803: {Head-worn items, e.g. helmets, masks, headphones or goggles} - A61H 23/0245: {with ultrasonic transducers, e.g. piezoelectric} - A61M 21/00: Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis - A61N 5/0618: {Psychological treatment} - A61N 5/0622: {Optical stimulation for exciting neural tissue} - A61B 5/16: Devices for psychotechnics (using teaching or educational appliances G09B1/00 - G09B7/00); Testing reaction times {; Devices for evaluating the psychological state} - A61H 2201/1604: Head - A61H 2201/165: Wearable interfaces - A61H 2201/50: Control means thereof - A61H 2201/5097: wireless - A61H 2230/065: used as a control parameter for the apparatus - A61H 2230/305: used as a control parameter for the apparatus (A61H2230/045 takes precedence) - A61H 2230/505: used as a control parameter for the apparatus - A61H 2230/605: used as a control parameter for the apparatus - A61M 2021/0022: {by the tactile sense, e.g. vibrations} - A61M 2021/0027: {by the hearing sense} - A61M 2021/0044: {by the sight sense} - A61M 2021/005: {images, e.g. video} - A61M 2205/3306: Optical measuring means - A61M 2205/332: Force measuring means - A61M 2205/3569: sublocal, e.g. between console and disposable - A61M 2205/3592: using telemetric means, e.g. radio or optical transmission - A61M 2205/505: Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches - A61M 2209/088: on the body - A61M 2230/04: Heartbeat characteristics, e.g. ECG, blood pressure modulation - A61M 2230/10: Electroencephalographic signals - A61M 2230/18: Rapid eye-movements [REM] - A61M 2230/205: partial oxygen pressure (P-O2) - A61M 2230/30: Blood pressure (A61M2230/04 takes precedence) - A61M 2230/50: Temperature - A61M 2230/60: Muscle strain, i.e. measured on the user - A61M 2230/63: Motion, e.g. physical activity - A61M 2230/65: Impedance, e.g. conductivity, capacity - A61N 2005/0626: {Monitoring, verifying, controlling systems and methods} - A61N 2005/0648: {the light being directed to the eyes} - A61N 2005/0662: {Visible light} - A61H: PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY (electrotherapy, magnetotherapy, radiation therapy or ultrasound therapy A61N) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract Non-pharmaceuticals method of treating the effects of addiction withdrawal are described. The method includes providing a person with stimuli include visual and/or auditory stimuli which are pulsed at the rate of various types of brain waves. The use of the method lessens various withdrawal symptoms, such as anxiety, sleepiness, sweating, tearing of the eyes, running of the nose, goosebumps, shaking, hot flushes, cold flushes, bones aching, muscles aching, restlessness, nausea, vomiting, muscle twitching, stomach cramps, pain, the need to use an opioid, the desire to use an opioid, sleep disturbances. and the use of rescue medications. ## Claims ### Claim 1 A method comprising: selecting a person undergoing an addiction withdrawal and having one or more withdrawal symptoms; and treating the one or more withdrawal symptoms by administering a therapeutically effective amount of a sensory stimulus to the person; where said sensory stimulus comprises: one or more visual stimuli; and one or more auditory stimuli. ### Claim 2 (depends on 1) The method of claim 1, where said one or more withdrawal symptoms are chosen from sleepiness, sweating, tearing of eyes, running of a nose, goosebumps, shaking, hot flushes, cold flushes, aching bones, aching muscles, restlessness, nausea, vomiting, muscle twitching, stomach cramps, pain, a need to use an opioid, a desire to use an opioid, and sleep disturbances. ### Claim 3 (depends on 1) The method of claim 1, where the withdrawal symptoms result from opioid withdrawal. ### Claim 4 (depends on 1) The method of claim 1, where the withdrawal symptoms result from nicotine withdrawal. ### Claim 5 (depends on 1) The method of claim 1, where said method further reduces the person's use of rescue medications. ### Claim 6 (depends on 1) The method of claim 1, where said one or more visual stimuli include an amplitude modulated light source. ### Claim 7 (depends on 1) The method of claim 1, where one of said one or more visual stimuli includes a sinusoidally varying light source. ### Claim 8 (depends on 1) The method of claim 1, where one of said one or more auditory stimuli includes an amplitude modulated audio frequency. ### Claim 9 (depends on 1) The method of claim 1, where said sensory stimulus includes two or more sensory stimuli patterns including a first stimuli pattern that is different than a second stimuli pattern. ### Claim 10 (depends on 9) The method of claim 9, where said first stimuli pattern has a first pulse frequency and said second stimuli pattern has a second pulse frequency. ### Claim 11 (depends on 10) The method of claim 10, where said first stimuli pattern includes a first sinusoidal component that is between 3.75 Hz and 4.25 Hz, is between 1.25 Hz and 1.75 Hz, or is between 0.25 Hz and 0.75 Hz, and where said second stimuli pattern includes a second sinusoidal component that is between 3.75 Hz and 4.25 Hz, is between 1.25 Hz and 1.75 Hz, or is between 0.25 Hz and 0.75 Hz. ### Claim 12 (depends on 10) The method of claim 10, where said two or more sensory stimuli patterns includes a third stimuli pattern that is different than said first stimuli pattern and said second stimuli pattern. ### Claim 13 (depends on 12) The method of claim 12, where said first stimuli pattern includes a first sinusoidal component that is between 3.75 Hz and 4.25 Hz, is between 1.25 Hz and 1.75 Hz, or is between 0.25 Hz and 0.75 Hz, where said second stimuli pattern includes a second sinusoidal component that is between 3.75 Hz and 4.25 Hz, is between 1.25 Hz and 1.75 Hz, or is between 0.25 Hz and 0.75 Hz, and where said third stimuli pattern includes a third sinusoidal component that is between 3.75 Hz and 4.25 Hz, is between 1.25 Hz and 1.75 Hz, or is between 0.25 Hz and 0.75 Hz. ### Claim 14 (depends on 1) The method of claim 1, where said sensory stimulus alternates between a first sensory stimuli including simultaneously providing a left visual stimuli pattern to a left eye of the person and a right auditory stimuli pattern to the right side of a head of the person, and a second sensory stimuli including simultaneously providing a right visual stimuli pattern to a right eye of the person and a left auditory stimuli pattern to the left side of the head of the person, wherein one or more of the left auditory stimuli pattern or the right auditory stimuli pattern comprises a sequence of stimuli patterns including a first stimuli pattern, a second stimuli pattern, and a third stimuli pattern. ### Claim 15 (depends on 14) The method of claim 14, further comprising: periodically providing a sensory stimuli including simultaneously providing a left visual stimuli pattern to the left eye, a right visual stimuli pattern to the right eye, a left auditory stimuli pattern to the left side of the head, and a right auditory stimuli pattern to the right side of the head. ### Claim 16 (depends on 14) The method of claim 14, further comprising: alternating sensory stimuli between a third sensory stimuli including simultaneously providing a left visual stimuli pattern to the left eye and a left auditory stimuli pattern to the left side of the head, and a fourth sensory stimuli including simultaneously providing a right visual stimuli pattern to the right eye and a right auditory stimuli pattern to the right side of the head. ### Claim 17 (depends on 16) The method of claim 16, further comprising: alternating sensory stimuli between a fifth sensory stimuli including simultaneously providing a left auditory stimuli pattern to the left side of the head and a right auditory stimuli pattern to the right side of the head, and a sixth sensory stimuli including simultaneously providing a left visual stimuli pattern to the left eye and a right visual stimuli pattern to the right eye. ### Claim 18 (depends on 14) The method of claim 14, wherein the left auditory stimuli pattern comprises generating the left auditory stimuli pattern with a left speaker, and wherein generating the right auditory stimuli pattern comprises generating the right auditory stimuli pattern with a right speaker. ### Claim 19 (depends on 14) The method of claim 14, wherein the left auditory stimuli pattern comprises generating the left auditory stimuli pattern with a left bone conduction transducer of a headset, and wherein the right auditory stimuli pattern comprises generating the right auditory stimuli pattern with a right bone conduction transducer of the headset. ### Claim 20 (depends on 14) The method of claim 14, wherein one or more of the left or right auditory stimuli pattern includes an auditory frequency of from 240 Hz to 480 Hz. ### Claim 21 (depends on 14) The method of claim 14, wherein one or more of the left visual stimuli pattern or right visual stimuli pattern comprises repeatedly pulsing a light at one or more of a first pulse frequency, a second pulse frequency less than the first pulse frequency, or a third pulse frequency less than the first and second pulse frequencies. ### Claim 22 (depends on 21) The method of claim 21, wherein the first pulse frequency is between 3.75 Hz and 4.25 Hz, the second pulse frequency is between 1.25 Hz and 1.75 Hz, and the third pulse frequency is between 0.25 Hz and 0.75 Hz. ### Claim 23 (depends on 21) The method of claim 21, wherein repeatedly pulsing the light comprises pulsing the light for a predetermined time interval. ### Claim 24 (depends on 23) The method of claim 23, wherein the predetermined time interval is 25-45 seconds. ### Claim 25 (depends on 14) The method of claim 14, wherein the sequence of stimuli patterns each have a pulse frequency having a pulse period, where a portion of the pulse period includes a stimulus of an auditory frequency of from 240 Hz to 480 Hz. ### Claim 26 (depends on 25) The method of claim 25, wherein said portion of said pulse period is one half of the pulse period. ### Claim 27 (depends on 14) The method of claim 14, wherein said first stimuli pattern, said second stimuli pattern, or said third stimuli pattern stimulates for a predetermined time interval. ### Claim 28 (depends on 27) The method of claim 27, wherein the predetermined time interval is 25-35 seconds. ### Claim 29 (depends on 28) The method of claim 28, wherein the predetermined time interval is 30 seconds. ### Claim 30 (depends on 10) The method of claim 10, where said first stimuli pattern includes a first sinusoidal component corresponding to a first delta brain wave frequency, a first theta brain wave frequency, or a first alpha brain wave frequency, and where said second stimuli pattern includes a second sinusoidal component corresponding to a second delta brain wave frequency, a second theta brain wave frequency, or a second alpha brain wave frequency. ### Claim 31 (depends on 30) The method of claim 30, where said third stimuli pattern includes a third sinusoidal component corresponding to a third delta brain wave frequency, a third theta brain wave frequency, or a third alpha brain wave frequency, and where said second stimuli pattern includes a fourth sinusoidal component corresponding to a fourth delta brain wave frequency, a fourth theta brain wave frequency, or a fourth alpha brain wave frequency. ### Claim 32 (depends on 1) The method of claim 1, further comprising obtaining at least one measurement of the person using at least one sensor; determining a state of the person from the at least one obtained measurement; and modifying said sensory stimulus according to said determined state of the person. ### Claim 33 (depends on 32) The method of claim 32, where said at least one sensor includes at least one heart rate sensor, at least one heart rate variability (HRV) sensor, at least one temperature sensor, at least one motion sensor, at least one galvanic skin response sensor, at least one accelerometer at least one EEG, at least one EMG. ### Claim 34 (depends on 33) The method of claim 33, where said determined state of the person is a state of sleep or a level or change in a level of relaxation or arousal. ### Claim 35 (depends on 1) The method of claim 1, further comprising: providing a headset to be worn by the person; and administering, with the headset, the therapeutically effective amount of a sensory stimulus to the person. ### Claim 36 (depends on 35) The method of claim 35, where the withdrawal symptoms result from opioid withdrawal. ### Claim 37 (depends on 35) The method of claim 35, where the withdrawal symptoms result from nicotine withdrawal.