# US 11,298,469 B2 · Medicament delivery device > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,298,469 B2 - Document ID: US11298469B2 - Status: Granted - Kind: B2 - Application number: 16/346,248 - Filed: 2017-10-23 - Published: 2020-02-13 - Granted: 2022-04-12 - Earliest claimed: 2016-11-01 - Assignees: Sanofi-Aventis Deutschland GmbH - Applicants: Sanofi-Aventis Deutschland GMBH - Inventors: Thomas Klemm - Web page: https://patentgrep.com/patent/US11298469B2 ## CPC - A61M 5/422: {Desensitising skin} - A61M 5/3298: {Needles arranged in parallel} - A61M 37/0015: {by using microneedles} - A61M 5/322: {Retractable needles, i.e. disconnected from and withdrawn into the syringe barrel by the piston (devices for protecting guide needles in combination with catheters A61M25/0612)} - A61M 2037/0023: {Drug applicators using microneedles} - A61M 2202/048: Anaesthetics - A61M 2205/0205: Materials having antiseptic or antimicrobial properties, e.g. silver compounds, rubber with sterilising agent - A61M 2205/0238: the material being a coating or protective layer - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract A medicament delivery device includes a main injection needle for injecting a medicament into the body of a patient. The medicament delivery device includes a pain reduction device for releasing a pain reduction agent into the body of the patient prior the medicament injection. The pain reduction device includes an array of microneedles. ## Claims ### Claim 1 A medicament delivery device comprising: a main injection needle for injecting a medicament into a body of a patient; a pain reduction device for releasing a pain reduction agent into the body of the patient prior to injection of the medicament, wherein the pain reduction device comprises an array of microneedles, and wherein the main injection needle is extendable through the array of microneedles; and an activation mechanism configured to trigger the release of the pain reduction agent prior to triggering the injection of the medicament, wherein the main injection needle is movable between a storage position in which the main injection needle is at least partially retracted in the device, and a use position in which a proximal end of the main injection needle protrudes from the device, and wherein the activation mechanism is configured to drive the array of microneedles from a retracted position towards a deployed position prior to driving the main injection needle from the storage position towards the use position. ### Claim 2 (depends on 1) The medicament delivery device according to claim 1, wherein in the retracted position, each microneedle is at least partially retracted in the device, and in the deployed position, a proximal end of each microneedle protrudes from the device. ### Claim 3 (depends on 2) The medicament delivery device according to claim 2, wherein the activation mechanism is configured to trigger the release of the pain reduction agent prior to triggering the injection of the medicament. ### Claim 4 (depends on 1) The medicament delivery device according to claim 1, wherein the pain reduction device comprises a chamber for storing the pain reduction agent. ### Claim 5 (depends on 1) The medicament delivery device according to claim 1, wherein the pain reduction device comprises a coating of the pain reduction agent, the coating disposed on a surface of the array of microneedles. ### Claim 6 (depends on 1) The medicament delivery device according to claim 1, wherein the array of microneedles comprises between 70 and 7000 microneedles. ### Claim 7 (depends on 1) The medicament delivery device according to claim 1, wherein the array of microneedles is substantially circular and has a diameter of between 10 and 30 millimeters. ### Claim 8 (depends on 1) The medicament delivery device according to claim 1, wherein each microneedle has a length between 0.2 and 3 millimeters. ### Claim 9 (depends on 1) The medicament delivery device according to claim 1, wherein each microneedle has a circular cross-section and has a diameter of between 40 and 150 micrometers. ### Claim 10 (depends on 1) The medicament delivery device according to claim 1, wherein the pain reduction agent comprises an anesthetic. ### Claim 11 (depends on 1) The medicament delivery device according to claim 1, wherein the pain reduction agent comprises a locally acting narcotic agent. ### Claim 12 (depends on 11) The medicament delivery device according to claim 11, wherein the pain reduction agent comprises an anesthetic and the locally acting narcotic agent. ### Claim 13 (depends on 1) The medicament delivery device according to claim 1, further comprising a cartridge of the medicament. ### Claim 14 (depends on 1) The medicament delivery device according to claim 1, wherein the medicament delivery device is an auto-injector. ### Claim 15 (depends on 1) The medicament delivery device according to claim 1, wherein the activation mechanism is configured to trigger the release of the pain reduction agent prior to triggering the injection of the medicament.