# US 11,298,452 B2 · Extracorporeal ambulator assist lung > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,298,452 B2 - Document ID: US11298452B2 - Status: Granted - Kind: B2 - Application number: 16/139,015 - Filed: 2018-09-22 - Published: 2019-01-24 - Granted: 2022-04-12 - Earliest claimed: 2012-11-28 - Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education; Carnegie Mellon University - Applicants: University of Pittsburgh—Of the Commonwealth System of Higher Education; Carnegie Mellon University - Inventors: William J. Federspiel; Brian Joseph Frankowski; James F. Antaki; Christian Andres Bermudez; Richard Garrett Jeffries; William R. Wagner; Sang-Ho Ye - Web page: https://patentgrep.com/patent/US11298452B2 ## CPC - A61M 1/3667: {with assisted venous return} - A61M 1/1698: {Blood oxygenators with or without heat-exchangers (intracorporal A61M1/1678; manufacturing of membranes therefor B01D67/00; semi-permeable membranes for separation processes characterised by their properties B01D69/00; semi-permeable membranes characterised by their material B01D71/00)} - A61M 1/262: {rotating} - A61M 1/267: {used for pumping} - A61M 1/32: Oxygenators without membranes - A61M 60/113: in other functional devices, e.g. dialysers or heart-lung machines - A61M 60/216: including a rotating member acting on the blood, e.g. impeller - A61M 60/38: Blood oxygenation - A61M 60/419: the force acting on the blood contacting member being permanent magnetic, e.g. from a rotating magnetic coupling between driving and driven magnets - A61M 60/81: Pump housings - A61M 2205/7536: allowing gas passage, but preventing liquid passage, e.g. liquophobic, hydrophobic, water-repellent membranes - A61M 2206/20: having means for promoting or enhancing the flow, actively or passively - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers may extend generally perpendicular to the direction of bulk flow of blood through the housing. ## Claims ### Claim 1 A extracorporeal system for lung assist comprising: a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a generally cylindrical fiber bundle comprising a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the generally cylindrical fiber bundle being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet, the plurality of hollow gas permeable fibers extending generally perpendicular to the direction of bulk flow of blood through the housing; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moveable element positioned external to the generally cylindrical fiber bundle which is axially spaced from and directly adjacent a surface of the generally cylindrical fiber bundle via which blood enters the generally cylindrical fiber bundle, movement of the at least one moveable element creating velocity fields in blood flow contacting the plurality of hollow gas permeable fibers. ### Claim 2 (depends on 1) The system of claim 1 wherein the system is a paracorporeal system. ### Claim 3 (depends on 2) The system of claim 2 wherein the plurality of hollow gas permeable fibers comprise a plurality of layers of fiber fabric, each of the plurality of layers of fiber fabric comprising hollow gas permeable fibers, wherein adjacent layers of fiber fabric are rotated relative to each other such that the orientation of the plurality of hollow gas permeable fibers in adjacent layers of fiber fabric are of a different orientation. ### Claim 4 (depends on 2) The system of claim 2 wherein the plurality of hollow gas permeable fibers comprise at least one zwitterionic species tethered on surfaces thereof. ### Claim 5 (depends on 2) The system of claim 2 wherein the system is adapted to adjustably deliver flows in the range of approximately 2 to 4 liters per minute. ### Claim 6 (depends on 2) The system claim 2 further comprising a first pivot bearing on a first side of the at least one moveable element and a second pivot bearing on a second side of the at least one moveable element. ### Claim 7 (depends on 2) The system of claim 2 wherein the at least one moving moveable element comprises a rotating impeller adapted to pump blood from the blood flow inlet to the blood flow outlet, the rotating impeller rotating in a plane generally parallel to an orientation of the plurality of hollow gas permeable fibers. ### Claim 8 (depends on 7) The system of claim 7 wherein a surface of the rotating impeller is directly adjacent the plurality of hollow gas permeable fibers and rotation thereof causes active mixing within the plurality of hollow gas permeable fibers. ### Claim 9 (depends on 7) The system of claim 7 wherein the impeller comprises a disk, a first plurality of vanes on a first side of the disk and a second set of vanes on a second side of the disk. ### Claim 10 (depends on 7) The system of claim 7 further comprising a rotating element positioned within the housing adjacent to the plurality of hollow gas permeable fibers on an opposite side thereof of the rotating impeller. ### Claim 11 (depends on 10) The system of claim 10 wherein the rotating element is a second impeller. ### Claim 12 (depends on 7) The system of claim 7 including a system to offset hydrodynamic force. ### Claim 13 (depends on 12) The system of claim 12 wherein the system to offset hydrodynamic force comprises a first magnet in operative connection with the rotating impeller which cooperates with a second magnet to create a repellant force therebetween. ### Claim 14 (depends on 1) The system of claim 1 wherein blood is blocked from flowing to the gas inlet and the gas outlet. ### Claim 15 (depends on 1) The system of claim 1 wherein the generally cylindrical fiber bundle is formed from a plurality of layers of fiber fabric, each of the plurality of layers of fiber fabric comprising hollow gas permeable fibers, wherein adjacent layers of fiber fabric are rotated relative to each other such that the orientation of the plurality of hollow gas permeable fibers in adjacent layers of fiber fabric are of a different orientation. ### Claim 16 (depends on 15) The system of claim 15 wherein a first seal is formed between the generally cylindrical fiber bundle and the housing at a first position and a second seal is formed between the generally cylindrical fiber bundle and the housing at a second position, rotated around the circumference of the generally cylindrical fiber bundle from the first position, to form a gas inlet manifold in fluid connection with the gas inlet on a first side of the first seal and the second seal and a gas outlet manifold in fluid connection with the gas outlet on a second side of the first seal and the second seal, the first seal and the second seal blocking fluid connection between the gas inlet manifold and the gas outlet manifold. ### Claim 17 A method for extracorporeal lung assist comprising: providing a generally cylindrical fiber bundle comprising a plurality of hollow gas permeable fibers within a housing, the plurality of hollow gas permeable fibers being adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the generally cylindrical fiber bundle being positioned between a blood flow inlet and a blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet, the plurality of hollow gas permeable fibers extending generally perpendicular to the direction of bulk flow of blood through the housing; flowing a sweep gas including oxygen through the plurality of hollow gas permeable fibers; and moving at least one moveable element positioned external to the generally cylindrical fiber bundle which is axially spaced from and directly adjacent a surface of the generally cylindrical fiber bundle via which blood enters the generally cylindrical fiber bundle, movement of the at least one moveable element creating velocity fields in blood flow contacting the plurality of hollow gas permeable fibers. ### Claim 18 (depends on 17) The method of claim 17 wherein paracorporeal lung assist is provided. ### Claim 19 A extracorporeal system for lung assist comprising: a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a generally cylindrical fiber bundle comprising a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the generally cylindrical fiber bundle being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; at least one moveable element positioned external to the generally cylindrical fiber bundle which is axially spaced from and directly adjacent a surface of the generally cylindrical fiber bundle via which blood enters the generally cylindrical fiber bundle, movement of the at least one moveable element creating velocity fields in blood flow contacting the plurality of hollow gas permeable fibers; a first pivot bearing on a first side of the at least one moveable element; and a second pivot bearing on a second side of the at least one moveable element. ### Claim 20 (depends on 19) The system of claim 19 wherein blood entering the housing flows across the first pivot bearing and the second pivot bearing to flush a surface of the first pivot bearing and a surface of the second pivot bearing.