# US 11,298,393 B2 · Composition comprising a mixture of an extract and bentonite

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- Number: US 11,298,393 B2
- Document ID: US11298393B2
- Status: Granted
- Kind: B2
- Application number: 16/306,199
- Filed: 2017-06-02
- Published: 2021-07-29
- Granted: 2022-04-12
- Earliest claimed: 2016-06-03
- Applicants: Jens Steen Olsen
- Inventors: Jens Steen Olsen
- Web page: https://patentgrep.com/patent/US11298393B2

## CPC

- A61K 36/48: Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K 8/04: Dispersions; Emulsions
- A61K 8/21: Fluorides; Derivatives thereof
- A61K 8/25: Silicon; Compounds thereof
- A61K 8/345: {containing more than one hydroxy group}
- A61K 8/466: {containing sulfonic acid derivatives; Salts}
- A61K 8/731: {Cellulose; Quaternized cellulose derivatives}
- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61K 9/0056: {Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals}
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 9/16: Agglomerates; Granulates; Microbeadlets {; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction (A61K9/20 takes precedence if the final form is a tablet; microspheres with drug-free outer coating, microcapsules A61K9/50; mixture of different granules, microcapsules, (coated) microparticles A61K9/5084; nanoparticles A61K9/51)}
- A61K 33/00: Medicinal preparations containing inorganic active ingredients
- A61K 33/12: Magnesium silicate
- A61K 35/02: from inanimate materials (carbon A61K33/44)
- A61K 47/02: Inorganic compounds
- A61K 47/20: containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
- A61K 47/26: Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A61K 47/38: Cellulose; Derivatives thereof
- A61P 31/04: Antibacterial agents
- A61P 31/12: Antivirals
- A61P 31/18: for HIV
- A61P 31/22: for herpes viruses
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61K 2236/10: Preparation or pretreatment of starting material
- A61K 2236/33: involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K 2236/51: Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
- A61K 2800/70: Biological properties of the composition as a whole
- A61K 2800/84: Products or compounds obtained by lyophilisation, freeze-drying
- A61K 2800/92: Oral administration
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

A composition including a mixture of Trigonella foenum-graecum extract and bentonite. The mixture is applicable in several technological fields, including the pharmacological, cosmetic, and veterinary field. Notably, the composition is useful in the treatment of a viral infection. The composition is synergistic in the sense that the mixture of Trigonella foenum-graecum extract and bentonite has a higher efficiency than each of the components alone.

## Claims

### Claim 1

A composition comprising a mixture of Trigonella foenum-graecum extract and bentonite with synergistic effect, wherein the Trigonella foenum-graecum extract is aqueous and obtainable by the steps of:
a) preparing a mixture of seeds of Trigonella foenum-graecum and liquid,
b) incubating said mixture for at least 3 hours,
c) heating of said mixture, and
recovering a liquid extract from mixture by separating remaining plant material from the mixture.

### Claim 2 (depends on 1)

The composition according to claim 1, wherein the incubation in step b) is continued until the sprouting is visible.

### Claim 3 (depends on 1)

The composition according to claim 1, wherein the heating of the mixture is conducted at least until the embryo is released from the seeds.

### Claim 4 (depends on 1)

The composition according to claim 1, wherein the recovered liquid extract is purified by gel filtration, HPLC, or extraction.

### Claim 5 (depends on 1)

The composition according to claim 1, wherein the recovered liquid extract is concentrated by removal of solvent.

### Claim 6 (depends on 5)

The composition according to claim 5, wherein the solvent partly or entirely is removed by a method selected among the group consisting of: membrane filtration, evaporation, precipitation, extraction, azeotrope distillation, lyophilisation, spray drying and combinations thereof.

### Claim 7 (depends on 1)

The composition according to claim 1, wherein Trigonella foenum-graecum extract is spray dried particles.

### Claim 8 (depends on 1)

The composition according to claim 1, wherein bentonite comprises 50% by weight or more of smectite.

### Claim 9 (depends on 8)

The composition according to claim 8, wherein the smectite is selected among montmorillonite, beidellite, sauconite, stevensite hectorite, saponite, nontronite, vermiculite, and mixtures thereof.

### Claim 10 (depends on 1)

The composition according to claim 1, comprising 1:10 to 10:1 by weight dry matter of Trigonella foenum-graecum extract to bentonite.

### Claim 11 (depends on 1)

The composition according to claim 1, wherein the weight of the mixture of Trigonella foenum-graecum extract and bentonite is at least 0.01% by weight of the final formulation.

### Claim 12 (depends on 1)

A pharmaceutical composition comprising a mixture of Trigonella foenum-graecum extract and bentonite according to claim 1, wherein said pharmaceutical composition is formulated as a gel, cream, mouth-wash, chewing gum, tooth-paste, balm, plaster, lip salve, spray, liquid, ointment, capsule, drop, or tablet.

### Claim 13 (depends on 1)

A method for prevention or treatment of a viral infection comprising the step of administering a composition according to claim 1 to a subject in need thereof.

### Claim 14 (depends on 13)

The method according to claim 13, wherein said virus is selected from the group of viruses having a lipid membrane.

### Claim 15 (depends on 14)

The method according to claim 14, wherein the virus is herpes simplex virus (HSV), influenza virus, human papilloma virus (HPV) or human immunodeficiency virus (HIV).