# US 11,298,357 B2 · Bovine supplement for neonatal calves > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,298,357 B2 - Document ID: US11298357B2 - Status: Granted - Kind: B2 - Application number: 16/117,227 - Filed: 2018-08-30 - Published: 2020-03-05 - Granted: 2022-04-12 - Earliest claimed: 2018-08-30 - Assignees: Techmix, Inc. - Applicants: Techmix, LLC - Inventors: Nathan C. Upah; Aaron N. Fritchen; Dennis M. McKilligan; Bradley W. Kolstad - Web page: https://patentgrep.com/patent/US11298357B2 ## CPC - A61K 31/522: having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir - A23K 10/30: from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms (obtained by microbiological or biochemical processes, e.g. using yeasts or enzymes, A23K10/10) - A23K 20/10: Organic substances - A23K 20/158: Fatty acids; Fats; Products containing oils or fats - A23K 20/163: Sugars; Polysaccharides - A23K 20/20: Inorganic substances, e.g. oligoelements - A23K 20/22: Compounds of alkali metals - A23K 50/10: for ruminants - A23K 50/60: for weanlings - A61K 9/006: {Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays} - A61K 9/08: Solutions {(composition of solutions A61K47/00)} - A61K 36/82: Theaceae (Tea family), e.g. camellia - A61K 47/12: Carboxylic acids; Salts or anhydrides thereof - A61K 47/36: Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin - A61K 47/44: Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin (synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A23K: FODDER ## Abstract The present invention relates generally to a feed supplement preparation for administration to ruminant animals and, more particularly, to a formulation for an oral bovine supplement for neonatal calves that delivers naturally occurring caffeine, antioxidants and other electrolytes in a stable liquid form of moderate viscosity. ## Claims ### Claim 1 A neonatal bovine dietary supplement that delivers a dose of a naturally occurring source of caffeine to a neonatal calf, the supplement comprising non-synthetic caffeine in the form of green tea extract which is present in an amount of 1-15% wt, and a viscosity adjustor in liquid form, wherein a viscosity of the supplement is 400-800 centipoise at 21 degrees Celsius such that the supplement is absorbed through the oral mucosal lining of the neonatal calf. ### Claim 2 (depends on 1) The neonatal bovine dietary supplement of claim 1, wherein the viscosity adjustor comprises corn syrup and xanthan gum. ### Claim 3 (depends on 1) The neonatal bovine dietary supplement of claim 1 further comprising sodium citrate and vegetable oil defoaming agent for facilitating suspension of the green tea extract in the supplement. ### Claim 4 (depends on 3) The neonatal bovine dietary supplement of claim 3, wherein the sodium citrate is sodium citrate dihydrate. ### Claim 5 (depends on 1) The neonatal bovine dietary supplement of claim 1 further comprising an antioxidant. ### Claim 6 (depends on 1) The neonatal bovine dietary supplement of claim 1 further comprising electrolytes. ### Claim 7 (depends on 6) The neonatal bovine dietary supplement of claim 6, wherein the electrolytes comprise sodium citrate or sodium citrate dihydrate. ### Claim 8 A neonatal bovine dietary supplement that delivers a dose of a naturally occurring source of caffeine to a neonatal calf, the supplement comprising non-synthetic caffeine in the form of green tea extract, and a viscosity adjustor in liquid form, wherein a viscosity of the supplement is 400-800 centipoise at 21 degrees Celsius such that the supplement is absorbed through the oral mucosal lining of the neonatal calf, wherein the green tea extract contains a concentrated amount of caffeine so that a 10-40 ml liquid dose of the supplement delivers 100-400 mg caffeine to the neonatal calf. ### Claim 9 A neonatal bovine dietary supplement that delivers a dose of a naturally occurring source of caffeine to a neonatal calf, the supplement comprising green tea extract, xanthan gum, corn syrup, and water, wherein the corn syrup is present in the supplement in an amount of 40-75% wt, and wherein the viscosity of the supplement is 400-800 centipoise at 21 degrees Celsius such that the supplement is absorbed through the oral mucosal lining of the neonatal calf. ### Claim 10 A neonatal bovine dietary supplement that delivers a dose of a naturally occurring source of caffeine to a neonatal calf, the supplement comprising green tea extract, xanthan gum, corn syrup, and water, wherein the green tea extract in the supplement is about 2-3% wt. ### Claim 11 A method of use of a neonatal bovine dietary supplement containing a naturally occurring source of caffeine for a new-born calf, said method comprising: (a) being presented with a new-born calf suffering from bovine dystocia; (b) administering to the calf a dose of the supplement comprising non-synthetic caffeine and a viscosity adjustor in liquid form, wherein a viscosity of the supplement is 400-800 centipoise at 21 degrees Celsius; and (c) wherein the supplement is absorbed through the oral mucosal lining of the calf. ### Claim 12 (depends on 11) The method of claim 11, wherein the naturally occurring caffeine is provided by a green tea extract. ### Claim 13 (depends on 11) The method of claim 11, wherein the viscosity adjustor comprises corn syrup and xanthan gum. ### Claim 14 (depends on 12) The method of claim 12, wherein the supplement dose comprises 10-40 ml of liquid and the dose of the supplement delivers 100-400 mg caffeine to the neonatal calf.