Subcutaneous delivery of polymer conjugates of therapeutics agents

A method for treating a disease or condition related to dopamine insufficiency in the peripheral or central nervous system in a subject, the method comprising the step of administering to the subject a poly(oxazoline) polymer conjugate comprising a water soluble poly(oxazoline) polymer and a dopamine agonist, wherein a release profile of the dopamine agonist is selectable based on the selection of the poly(oxazoline) polymer conjugate, the poly(oxazoline) polymer conjugate having the structure:

• wherein
• L is R3 forms a linkage with the poly(oxazoline) polymer;
• R4 is —CH2—C(O)—O—, —CH(CH3)—C(O)—O—, —CH2—CH2—C(O)—O—, —CH2—CH2—CH2—C(O)—O—, —CH2—O—C(O)—, —CH2(CH3)—O—C(O)—, —CH2—CH2—O—C(O)—or —CH2—CH2—CH2—O—C(O)—;
• R is an initiating group;
• R1 is a non-reactive group;
• A is the dopamine agonist;
• a is ran which indicates a random copolymer or block which indicates a block copolymer;
• o is from 1-50;
• m is from 1-1000;
• and
• T is a terminating group, wherein the release profile is dependent on the selection of R4.

A method for treating a disease or condition related tO dopamine insufficiency in the peripheral or central nervous system in a subject, the method comprising the step of subcutaneously administering to the subject a therapeutically effective amount of a poly(oxazoline) polymer conjugate comprising a water soluble poly(oxazoline) polymer and an agent, wherein the agent is a dopamine agonist, an adenosine A2A receptor antagonist, an anticholinergic, a monamine oxidase-B inhibitor or a catechol-O-methyl transferase inhibitor, and wherein a release profile of the agent is selectable based on the selection of the poly(oxazoline) polymer conjugate, the poly(oxazoline) polymer conjugate having the structure:

• wherein
• L is
• R3 forms a linkage with the poly(oxazoline) polymer;
• R4 is —CH2—C(O)—O—, —CH(CH3)—C(O)—O—, —CH2—CH2—C(O)—O—, —CH2—CH2—CH2—C(O)—O—, —CH2—O—C(O)—, —CH2(CH3)—O—C(O)—, —CH2—CH2—O—C(O)—or —CH2—CH2—CH2—O—C(O)—;
• R is an initiating group;
• R1 is a non-reactive group;
• A is the agent;
• a is ran which indicates a random copolymer or block which indicates a block copolymer;
• o is from 1-50;
• m is from 1-1000;
• and
• T is a terminating group, wherein the release profile is dependent on the selection of R4.