# US 11,298,349 B2 · Processes for preparing quinoline compounds and pharmaceutical compositions containing such compounds

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- Number: US 11,298,349 B2
- Document ID: US11298349B2
- Status: Granted
- Kind: B2
- Application number: 17/170,275
- Filed: 2021-02-08
- Published: 2021-06-03
- Granted: 2022-04-12
- Earliest claimed: 2011-02-10
- Assignees: Exelixis, Inc.
- Applicants: Exelixis, Inc.
- Inventors: Jo Ann Wilson; Khalid Shah
- Web page: https://patentgrep.com/patent/US11298349B2

## CPC

- A61K 31/47: Quinolines; Isoquinolines
- A61P 35/00: Antineoplastic agents
- C07D 215/233: only one oxygen atom which is attached in position 4
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

The present invention is directed to processes for making and compositions containing quinolines such as formula I or pharmaceutically acceptable salts thereof wherein: X1 is H, Br, CI, or X2 is H, Br, CI, or n1 is 1-2; and n2 is 1-2.

## Claims

### Claim 1

A pharmaceutical composition for oral administration comprising Compound IB;
one or more fillers; one or more disintegrants; one or more glidants; and one or more lubricants, wherein the pharmaceutical composition is a tablet or capsule pharmaceutical composition, and wherein the pharmaceutical composition is essentially free of process byproducts or contaminants.

### Claim 2 (depends on 1)

The pharmaceutical composition of claim 1, wherein the process byproduct or contaminant is 6,7-dimethoxy-quinoline-4-ol in the pharmaceutical composition.

### Claim 3

A pharmaceutical composition for oral administration comprising Compound IB;
one or more fillers; one or more disintegrants; one or more glidants; and one or more lubricants, wherein the pharmaceutical composition is a tablet or capsule pharmaceutical composition; and
wherein the pharmaceutical composition is essentially free of 6,7-dimethoxy-quinoline-4-ol.