# US 11,298,338 B2 · Compositions and methods for cancer therapy

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- Number: US 11,298,338 B2
- Document ID: US11298338B2
- Status: Granted
- Kind: B2
- Application number: 16/307,240
- Filed: 2017-06-06
- Published: 2019-07-18
- Granted: 2022-04-12
- Earliest claimed: 2016-06-06
- Assignees: University of Iowa Research Foundation
- Applicants: University of Iowa Research Foundation
- Inventors: Fenghuang Zhan; Ivana Frech; Guido Tricot
- Web page: https://patentgrep.com/patent/US11298338B2

## CPC

- A61K 31/375: Ascorbic acid, i.e. vitamin C; Salts thereof
- A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)}
- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A61K 31/381: having five-membered rings
- A61K 31/4184: condensed with carbocyclic rings, e.g. benzimidazoles
- A61K 31/496: Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A61K 31/5377: not condensed and containing further heterocyclic rings, e.g. timolol
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 35/00: Antineoplastic agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention provides compositions and methods to treat a hyperproliferative disorder with ascorbate or a pharmaceutically acceptable salt thereof, and one or more anti-cancer therapies.

## Claims

### Claim 1

A method of treating a hyperproliferative disorder associated with high intracellular iron comprising administering pharmacological ascorbic acid or a pharmaceutically acceptable salt thereof and melphalan, wherein the pharmacological ascorbic acid is administered at a dose of about 15 g-100 g, wherein the hyperproliferative disorder is smoldering multiple myeloma.

### Claim 2 (depends on 1)

The method of claim 1, wherein the melphalan is administered at a dosage of about 2 mg/m2 to 200 mg/m2.

### Claim 3 (depends on 1)

The method of claim 1, wherein the pharmacological ascorbic acid and the melphalan are administered simultaneously or sequentially.

### Claim 4 (depends on 1)

The method of claim 1, further comprising administering a proteasome inhibitor.

### Claim 5 (depends on 4)

The method of claim 4, wherein the pharmacological ascorbic acid and the proteasome inhibitor are administered simultaneously or sequentially.

### Claim 6 (depends on 1)

The method of claim 1, further comprising administering an anti-cancer therapy.

### Claim 7 (depends on 6)

The method of claim 6, wherein the anti-cancer therapy is immunotherapy or biologic therapy.

### Claim 8 (depends on 1)

The method of claim 1, wherein the melphalan is administered at a dosage of about 50 mg/m2 and 100 mg/m2.