# US 11,298,337 B2 · Parthenolide and its derivative for use in the treatment of axonal damage

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- Number: US 11,298,337 B2
- Document ID: US11298337B2
- Status: Granted
- Kind: B2
- Application number: 16/555,461
- Filed: 2019-08-29
- Published: 2019-12-26
- Granted: 2022-04-12
- Earliest claimed: 2015-04-20
- Assignees: Ruhr-UniversitäT Bochum
- Applicants: Ruhr-UniversitäT Bochum
- Inventors: Philipp Ludwig Alexander Gobrecht; Dietmar Fischer
- Web page: https://patentgrep.com/patent/US11298337B2

## CPC

- A61K 31/365: Lactones
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/02: for peripheral neuropathies
- A61P 25/04: Centrally acting analgesics, e.g. opioids
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61P 27/02: Ophthalmic agents
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to a compound reducing microtubule detyrosination in axonal tips selected from the group consisting of tubulin carboxypeptidase inhibitors and tubulin tyrosine ligase activators and combinations thereof for use in the treatment of axonal damage.

## Claims

### Claim 1

A method of regenerating axonal damage, wherein the axonal damage is an injury of the sciatic nerve, the method comprising administering to a subject a therapeutically effective amount of a compound reducing microtubule detyrosination in axonal tips selected from cnicin or a pharmaceutically acceptable salt thereof.

### Claim 2

A method of regenerating axonal damage, wherein the axonal damage is an axotomy of the sciatic nerve, the method comprising administering to a subject a therapeutically effective amount of a compound reducing microtubule detyrosination in axonal tips selected from cnicin or a pharmaceutically acceptable salt thereof.