# US 11,298,317 B2 · Alcoholic compositions having a lowered risk of acetaldehydemia > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,298,317 B2 - Document ID: US11298317B2 - Status: Granted - Kind: B2 - Application number: 16/941,959 - Filed: 2020-07-29 - Published: 2021-02-11 - Granted: 2022-04-12 - Earliest claimed: 2009-08-21 - Assignees: Deuteria Beverages, LLC - Applicants: Deuteria Beverages, LLC - Inventors: Anthony W. Czarnik; Jeffrey A. McKinney - Web page: https://patentgrep.com/patent/US11298317B2 ## CPC - A61K 9/0095: {Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches (A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006)} - A61K 9/08: Solutions {(composition of solutions A61K47/00)} - A61K 31/045: Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates - A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers - A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00) - A61P 25/32: Alcohol-abuse - A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 - C12C 12/00: Processes specially adapted for making special kinds of beer - C12G 3/05: with health-improving ingredients, e.g. flavonoids, flavones, polyphenols or polysaccharides - A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - C12C: BEER; PREPARATION OF BEER BY FERMENTATION (ageing or ripening by storing C12H1/22; methods for reducing the alcohol content after fermentation C12H3/00; methods for increasing the alcohol content after fermentation C12H6/00; venting devices for casks, barrels or the like C12L9/00); PREPARATION OF MALT FOR MAKING BEER; PREPARATION OF HOPS FOR MAKING BEER - C12G: WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES (beer C12C); PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H - A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION ## Abstract The present invention provides beverages and pharmaceutical compositions containing a deuterated alcohol according to Formula 1, and provides methods for their manufacture and use. The compositions of the invention are expected to ameliorate some of the negative side effects associated with the consumption of alcohol, such as hangover and facial flushing. ## Claims ### Claim 1 A method of making a pharmaceutical composition, comprising: an active pharmaceutical ingredient and ethanol, comprising the step of combining the active pharmaceutical ingredient with a deuterated alcohol having the formula wherein each H may independently be hydrogen or deuterium, in an amount sufficient to produce a composition wherein at least 5 mole percent of the ethanol in the composition is said deuterated alcohol. ### Claim 2 (depends on 1) The method according to claim 1, wherein the deuterated alcohol has the formula ### Claim 3 (depends on 1) The method according to claim 1, wherein the deuterated alcohol has the formula ### Claim 4 (depends on 1) The method according to claim 1, wherein the deuterated alcohol has the formula ### Claim 5 (depends on 1) The method according to claim 1, wherein the deuterated alcohol has the formula CD3CD2OH. ### Claim 6 (depends on 1) The method according to claim 1, wherein from 1 to 40% by weight of the composition is ethanol. ### Claim 7 (depends on 1) The method according to claim 1, wherein from 0.25 to 60% by weight of the composition is deuterated ethanol. ### Claim 8 (depends on 1) The method according to claim 1, wherein from 50 to 100% by weight of the ethanol in the composition is deuterated ethanol. ### Claim 9 (depends on 1) The method according to claim 1, wherein the pharmaceutical composition, further comprises: water. ### Claim 10 (depends on 1) The method according to claim 1, wherein the pharmaceutical composition, further comprises: a pharmaceutically acceptable excipient. ### Claim 11 (depends on 1) The method according to claim 1, wherein the pharmaceutical composition, further comprises: water and a pharmaceutically acceptable excipient. ### Claim 12 (depends on 1) The method according to claim 1, wherein at least 15 mole percent of the ethanol is said deuterated alcohol. ### Claim 13 (depends on 1) The method according to claim 1, wherein at least 30 mole percent of the ethanol is said deuterated alcohol. ### Claim 14 (depends on 1) The method according to claim 1, wherein at least 50 mole percent of the ethanol is said deuterated alcohol. ### Claim 15 (depends on 1) The method according to claim 1, wherein at least 75 mole percent of the ethanol is said deuterated alcohol. ### Claim 16 (depends on 1) The method according to claim 1, wherein at least 95 mole percent of the ethanol is said deuterated alcohol.