# US 11,298,316 B2 · Topical copper ion treatments and methods of treatment using topical copper ion treatments in the oral-respiratory-otic areas of the body > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,298,316 B2 - Document ID: US11298316B2 - Status: Granted - Kind: B2 - Application number: 17/231,764 - Filed: 2021-04-15 - Published: 2021-07-29 - Granted: 2022-04-12 - Earliest claimed: 2013-03-15 - Assignees: Cda Research Group, Inc. - Applicants: CDA Research Group, Inc. - Inventors: ChunLim Abbott; Dominic C. Abbott - Web page: https://patentgrep.com/patent/US11298316B2 ## CPC - A61K 9/006: {Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays} - A61K 8/19: containing inorganic ingredients - A61K 9/0036: {Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms} - A61K 9/0043: {Nose} - A61K 9/0046: {Ear} - A61K 9/02: Suppositories; Bougies; Bases therefor; {Ovules}(apparatus for making A61J3/08; devices for introducing into the body A61M31/00) - A61K 33/34: Copper; Compounds thereof - A61P 1/02: Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis - A61P 11/00: Drugs for disorders of the respiratory system - A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract Copper ion treatments and methods of treatment are provided to treat various body conditions affecting the oral, respiratory and/or otic areas of the body. The copper ion treatments contain copper ions which bring about local and systemic therapeutic effects as a result of contacting anatomical tissue of the oral cavity, the nasal passages or ear canal. The copper ion treatments and methods involve copper ion-containing solutions, copper ion toothpaste and copper ion mouthwash. The copper ion-containing solutions can be delivered to the oral cavity by spraying or swabbing, can be delivered to the nostrils as spray, drops, or by swabbing, and can be delivered to the ear canal as spray, drops, or by swabbing. The copper ion toothpaste is used for brushing the teeth, and the copper ion mouthwash is used for rinsing the mouth. ## Claims ### Claim 1 A method of treating conditions affecting the oral cavity, consisting of the steps of spraying into the oral cavity a copper ion-containing solution consisting of copper ions, a biocompatible saline solution, and a buffer, wherein the buffer has a pH of 5±0.4, wherein the copper ions are disposed in the copper ion-containing solution as a result of leaching the copper ions from a solid copper metal disposed in the biocompatible saline solution and buffer, wherein the solid copper metal is a copper alloy, and wherein the buffer is a biocompatible solution consisting of a solvent, acetic acid, and acetate; and repeating said step of spraying for a number of consecutive days. ### Claim 2 (depends on 1) The method of treating recited in claim 1 wherein said step of spraying includes spraying the copper ion-containing solution from a spray pump nozzle into a throat. ### Claim 3 (depends on 1) The method of treating recited in claim 1 wherein said step of spraying includes spraying the copper ion-containing solution from a spray pump nozzle onto a canker sore, mouth sore or mouth ulcer within the oral cavity. ### Claim 4 (depends on 1) The method of treating recited in claim 1 wherein said step of spraying includes spraying the copper ion-containing solution from a spray pump nozzle onto a gum area that is sore, inflamed, or infected. ### Claim 5 (depends on 1) The method of treating recited in claim 1 wherein the conditions treated include bacterial, viral and/or fungal conditions. ### Claim 6 (depends on 1) The method of treating recited in claim 1 wherein spraying the copper ion-containing solution into the oral cavity kills bacteria, virus, and fungus present in the oral cavity. ### Claim 7 (depends on 1) The method of treating recited in claim 1, wherein the concentration of copper ions is between 0.04 mg/ml and 0.209 mg/ml. ### Claim 8 (depends on 1) The method of treating recited in claim 1, wherein the copper alloy is selected from the group consisting of a brass, a bronze, a copper-nickel, and a copper-nickel-zinc. ### Claim 9 A method of treating conditions affecting the oral cavity, consisting of the steps of: spraying into the oral cavity a copper ion-containing solution consisting of copper ions, a biocompatible saline solution, and a buffer comprising at least one of acetate and acetic acid, wherein the buffer has a pH of 5±0.4, wherein the copper ions are disposed in the copper ion-containing solution as a result of leaching the copper ions from a solid copper metal disposed in the biocompatible saline solution and buffer, wherein the solid copper metal is a copper alloy, and wherein the copper ion-containing solution is free or substantially free of active ingredients other than copper ions; and repeating said step of spraying for a number of consecutive days. ### Claim 10 (depends on 9) The method of treating recited in claim 9, wherein the copper alloy is selected from the group consisting of a brass, a bronze, a copper-nickel, and a copper-nickel-zinc. ### Claim 11 (depends on 9) The method of treating recited in claim 9 wherein said step of spraying includes spraying the copper ion-containing solution from a spray pump nozzle into a throat. ### Claim 12 (depends on 9) The method of treating recited in claim 9 wherein said step of spraying includes spraying the copper ion-containing solution from a spray pump nozzle onto a canker sore, mouth sore, or mouth ulcer within the oral cavity. ### Claim 13 (depends on 9) The method of treating recited in claim 9 wherein said step of spraying includes spraying the copper ion-containing solution from a spray pump nozzle onto a gum area that is sore, inflamed, or infected. ### Claim 14 (depends on 9) The method of treating recited in claim 9 wherein the conditions treated include bacterial, viral, and/or fungal conditions. ### Claim 15 (depends on 10) The method of treating recited in claim 10 wherein spraying the copper ion-containing solution into the oral cavity kills bacteria, virus, and fungus present in the oral cavity. ### Claim 16 (depends on 9) The method of treating recited in claim 9, wherein the concentration of copper ions is between 0.04 mg/ml and 0.209 mg/ml.