# US 11,298,312 B2 · Composition comprising niacinamide and picolinamide

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- Number: US 11,298,312 B2
- Document ID: US11298312B2
- Status: Granted
- Kind: B2
- Application number: 16/822,183
- Filed: 2020-03-18
- Published: 2020-07-23
- Granted: 2022-04-12
- Earliest claimed: 2015-10-05
- Assignees: Conopco, Inc.
- Applicants: Conopco, Inc.
- Inventors: Amitabha Majumdar; Mruthyunjaya Swamy Mathapathi
- Web page: https://patentgrep.com/patent/US11298312B2

## CPC

- A61K 8/675: {Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde (tocopheryl nicotinate A61K8/678)}
- A61K 8/4926: {having six membered rings}
- A61K 31/4402: only substituted in position 2, e.g. pheniramine, bisacodyl
- A61K 31/455: Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
- A61P 17/00: Drugs for dermatological disorders
- A61P 31/02: Local antiseptics
- A61P 31/04: Antibacterial agents
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61Q 15/00: Anti-perspirants or body deodorants (deodorisation of air A61L9/00)
- A61Q 17/005: {Antimicrobial preparations}
- A61Q 19/02: for chemically bleaching or whitening the skin
- A61Q 19/10: Washing or bathing preparations
- A61K 2800/70: Biological properties of the composition as a whole
- Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

## Abstract

The present invention relates to a topical composition and more particularly a topical composition for antimicrobial benefit. According to the present invention there is provided a topical composition comprising Niacinamide and picolinamide wherein the molar ratio of Niacinamide to picolinamide is from I:20 to 20:I.

## Claims

### Claim 1

A topical composition comprising niacinamide and picolinamide to provide an antimicrobial benefit when applied to an external surface of the human body.

### Claim 2 (depends on 1)

The composition as claimed in claim 1, wherein the composition comprises 0.1 to 20% by weight of niacinamide.

### Claim 3 (depends on 1)

The composition as claimed in claim 1, wherein the composition comprises 1 to 5% by weight of niacinamide.

### Claim 4 (depends on 1)

The composition as claimed in claim 1, wherein the composition comprises 1 to 3% by weight of niacinamide.

### Claim 5 (depends on 1)

The composition as claimed in claim 1, wherein the composition comprises 0.1 to 20% by weight of picolinamide.

### Claim 6 (depends on 1)

The composition as claimed in claim 1, wherein the composition comprises 1 to 5% by weight of picolinamide.

### Claim 7 (depends on 1)

The composition as claimed in claim 1, wherein the composition comprises 1 to 3% by weight of picolinamide.

### Claim 8 (depends on 1)

The composition as claimed in claim 1, wherein the molar ratio of niacinamide to picolinamide is from 1:20 to 20:1.

### Claim 9 (depends on 1)

The composition as claimed in claim 1, wherein the molar ratio of niacinamide to picolinamide is from 1:15 to 15:1.

### Claim 10 (depends on 1)

The composition as claimed in claim 1, wherein the molar ratio of niacinamide to picolinamide is from 1:10 to 10:1.

### Claim 11 (depends on 1)

The composition as claimed in claim 1, wherein the molar ratio of niacinamide to picolinamide is from 1:2 to 2:1.

### Claim 12 (depends on 1)

The composition according to claim 1, further comprising a cosmetically accepted base.

### Claim 13 (depends on 1)

The composition according to claim 1, comprising a skin benefit agent.

### Claim 14 (depends on 13)

The composition according to claim 13, wherein the skin benefit agent comprises a skin-lightening agent.

### Claim 15 (depends on 14)

The composition according to claim 14, wherein the skin lightening agent comprises 2,4 resorcinol derivatives, 3,5 resorcinol derivatives, green tea extract, vitamins or mixtures thereof.

### Claim 16

A topical composition comprising picolinamide and green tea extract to provide a skin-lightening benefit.

### Claim 17 (depends on 1)

A method for inducing secretion of anti-microbial peptides (AMPs) when applied on an external surface of the human body using the composition of claim 1.

### Claim 18 (depends on 15)

The method as claimed in claim 15, wherein the method induces secretion of anti-microbial peptides (AMPs) from keratinocytes.