# US 11,298,307 B2 · Transparent or semitransparent cosmetic composition having enhanced amentoflavone stability > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,298,307 B2 - Document ID: US11298307B2 - Status: Granted - Kind: B2 - Application number: 16/499,367 - Filed: 2018-03-26 - Published: 2020-02-20 - Granted: 2022-04-12 - Earliest claimed: 2017-03-31 - Assignees: Amorepacific Corporation - Applicants: Amorepacific Corporation - Inventors: Byung Ryol Paik; Soon Ae An; Joon Young Hwang; Yong Jin Kim; Byung Fhy Suh - Web page: https://patentgrep.com/patent/US11298307B2 ## CPC - A61K 8/498: {having 6-membered rings or their condensed derivatives, e.g. coumarin} - A61Q 19/00: Preparations for care of the skin - A61K 8/345: {containing more than one hydroxy group} - A61K 8/36: Carboxylic acids; Salts or anhydrides thereof - A61K 8/37: Esters of carboxylic acids - A61K 8/42: Amides - A61K 8/4913: {having five membered rings, e.g. pyrrolidone carboxylic acid} - A61K 8/494: {with more than one nitrogen as the only hetero atom} - A61K 8/675: {Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde (tocopheryl nicotinate A61K8/678)} - A61K 8/97: from algae, fungi, lichens or plants; from derivatives thereof - A61Q 19/08: Anti-ageing preparations - A61K 2800/262: Transparent; Translucent - A61K 2800/52: Stabilizers - A61K 2800/88: Two- or multipart kits - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract The present invention relates to a transparent or semitransparent cosmetic composition in which the stability of amentoflavone is enhanced, and more particularly, to a transparent or semitransparent cosmetic composition, wherein a water-soluble amentoflavone-oligomer complex, in which amentoflavone is encapsulated in a hollow structure of an oligomer structure, is stabilized in a second agent containing a polyhydric alcohol, a two-liquid-type container is used to mix first and second agents before use, and hydrotrope is contained in the first agent to increase the mixing stability of the first and second agents and thereby enhance the stability of amentoflavone. ## Claims ### Claim 1 A cosmetic product comprising a transparent or semitransparent cosmetic composition having enhanced amentoflavone stability, said cosmetic product comprising: a first agent containing hydrotrope; a second agent consisting of a water-soluble amentoflavone-oligomer complex, a polyhydric alcohol for stabilizing the amentoflavone, and optionally distilled water or glycerin; and a two-liquid type container storing the first agent and the second agent, respectively, resulting in a mixture of the first agent and the second agent before use, wherein the water-soluble amentoflavone-oligomer complex encapsulates the amentoflavone in a cavity structure of an oligomer structure formed from a hydrophilic natural polymer, and wherein the water-soluble amentoflavone-oligomer complex is contained in an amount of 0.2 to 30% by weight based on the total weight of the second agent. ### Claim 2 (depends on 1) The cosmetic product according to claim 1, wherein the hydrotrope is one or more selected from the group consisting of niacinamide, caffeine, sodium pyrrolidone carbonic acid, sodium salicylate, urea, hydroxyethyl urea, and D-panthenol. ### Claim 3 (depends on 1) The cosmetic product according to claim 1, wherein the amentoflavone is in a form of a Selaginella tamariscina extract. ### Claim 4 (depends on 1) The cosmetic product according to claim 1, wherein the amentoflavone is encapsulated in the cavity structure in an amount of 7.6 to 9.2% by weight relative to the total weight of the water-soluble amentoflavone-oligomer complex. ### Claim 5 (depends on 1) The cosmetic product according to claim 1, wherein the water-soluble amentoflavone-oligomer complex is contained in an amount of 0.1 to 5% by weight based on the total weight of the transparent or semitransparent cosmetic composition. ### Claim 6 (depends on 1) The cosmetic product according to claim 1, wherein the polyhydric alcohol is a dihydric or trihydric alcohol having 3 to 6 carbon atoms. ### Claim 7 (depends on 1) The cosmetic product according to claim 1, wherein the polyhydric alcohol is at least one of propanediol and butanediol. ### Claim 8 (depends on 1) The cosmetic product according to claim 1, wherein the amentoflavone is contained in an amount of 0.0152 to 2.76% by weight based on the total weight of the second agent. ### Claim 9 (depends on 1) The cosmetic product according to claim 1, wherein the amentoflavone is contained in an amount of 0.0076 to 0.46% by weight based on the total weight of the transparent or semitransparent cosmetic composition. ### Claim 10 (depends on 1) The cosmetic product according to claim 1, wherein a mixing ratio of the first agent and the second agent is 1 to 6:1 on a weight basis. ### Claim 11 (depends on 1) The cosmetic product according to claim 1, wherein the second agent comprises distilled water or glycerin. ### Claim 12 (depends on 11) The cosmetic product according to claim 11, wherein the distilled water or glycerin is contained in an amount of greater than 0% by weight or less to 30% by weight based on the total weight of the second agent.