# US 11,298,300 B2 · Stable Pickering-type emulsions

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- Number: US 11,298,300 B2
- Document ID: US11298300B2
- Status: Granted
- Kind: B2
- Application number: 16/807,272
- Filed: 2020-03-03
- Published: 2021-09-09
- Granted: 2022-04-12
- Earliest claimed: 2020-03-03
- Assignees: Ciella James LLC
- Applicants: Ciella James LLC
- Inventors: Denise Kilburg
- Web page: https://patentgrep.com/patent/US11298300B2

## CPC

- A61K 8/06: Emulsions
- A61K 8/345: {containing more than one hydroxy group}
- A61K 8/361: {Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof}
- A61K 8/4973: {with oxygen as the only hetero atom}
- A61K 8/60: Sugars; Derivatives thereof
- A61K 2800/10: General cosmetic use
- A61K 2800/21: Emulsions characterized by droplet sizes below 1 micron
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The present disclosure provides stable Pickering-type emulsions comprising glycerin and oil, as well as methods of manufacturing the same. In some aspects, such emulsions further comprise magnesium stearate and a non-ionic surfactant as co-emulsifiers.

## Claims

### Claim 1

A Pickering-type emulsion, comprising:
a discontinuous internal phase, wherein the internal phase comprises a polyol in an amount of from about 15% to about 30% by weight of the entire emulsion;
a continuous external oil phase, in an amount of from about 55% to about 85% by weight of the entire emulsion; and
an emulsifier, wherein the emulsifier comprises magnesium stearate.

### Claim 2 (depends on 1)

The Pickering-type emulsion of claim 1, wherein the polyol is selected from the group consisting of ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, sorbitol, and diethylene glycol.

### Claim 3 (depends on 1)

The Pickering-type emulsion of claim 1, wherein the polyol is glycerin.

### Claim 4 (depends on 1)

The Pickering-type emulsion of claim 1, further comprising sorbitan olivate as a co-emulsifier.

### Claim 5 (depends on 1)

The Pickering-type emulsion of claim 1, wherein the discontinuous internal phase comprises spherical droplets having a diameter of 10-40 μm.

### Claim 6 (depends on 1)

The Pickering-type emulsion of claim 1, wherein the magnesium stearate is present in an amount of 1-3% by weight of the entire emulsion.

### Claim 7 (depends on 6)

The Pickering-type emulsion of claim 6, further comprising sorbitan olivate as a co-emulsifier in an amount of 1-3% by weight of the entire emulsion.

### Claim 8 (depends on 7)

The Pickering-type emulsion of claim 7, wherein the emulsion is stable for at least 48 hours at 60° C., displaying no visible phase separation.

### Claim 9 (depends on 7)

The Pickering-type emulsion of claim 7, wherein the emulsion is stable for at least 6 months at room temperature, displaying no visible phase separation.

### Claim 10 (depends on 1)

The Pickering-type emulsion of claim 1, wherein the magnesium stearate is localized to the interface between the discontinuous internal phase and the continuous external oil phase.

### Claim 11

A Pickering-type emulsion, comprising:
a discontinuous internal phase, wherein the internal phase comprises an oil in an amount of from about 5% to about 65% by weight of the entire emulsion;
a continuous external polyol phase, in an amount of from about 35% to about 95% by weight of the entire emulsion; and
an emulsifier, wherein the emulsifier comprises magnesium stearate.

### Claim 12 (depends on 11)

The Pickering-type emulsion of claim 11, wherein the polyol is selected from the group consisting of ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, sorbitol, and diethylene glycol.

### Claim 13 (depends on 11)

The Pickering-type emulsion of claim 11, wherein the polyol is glycerin.

### Claim 14 (depends on 11)

The Pickering-type emulsion of claim 11, further comprising sorbitan olivate as a co-emulsifier.

### Claim 15 (depends on 11)

The Pickering-type emulsion of claim 11, wherein the discontinuous internal phase comprises spherical droplets having a diameter of 10-40 μm.

### Claim 16 (depends on 11)

The Pickering-type emulsion of claim 11, wherein the magnesium stearate is present in an amount of 1-3% by weight of the entire emulsion.

### Claim 17 (depends on 16)

The Pickering-type emulsion of claim 16, further comprising sorbitan olivate as a co-emulsifier in an amount of 1-3% by weight of the entire emulsion.

### Claim 18 (depends on 17)

The Pickering-type emulsion of claim 17, wherein the emulsion is stable for at least 48 hours at 60° C., displaying no visible phase separation.

### Claim 19 (depends on 18)

The Pickering-type emulsion of claim 18, wherein the emulsion is stable for at least 6 months at room temperature, displaying no visible phase separation.

### Claim 20 (depends on 11)

The Pickering-type emulsion of claim 11, wherein the magnesium stearate is located at the interface between the discontinuous internal phase and the continuous external polyol phase.
