# US 11,298,290 B2 · Systems, devices, and methods for monitoring and modulation of therapeutic procedures

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 11,298,290 B2
- Document ID: US11298290B2
- Status: Granted
- Kind: B2
- Application number: 16/492,583
- Filed: 2018-03-09
- Published: 2021-05-13
- Granted: 2022-04-12
- Earliest claimed: 2017-03-09
- Assignees: Arizona Board of Regents on Behalf of the University of Arizona
- Applicants: Arizona Board of Regents on Behalf of the University of Arizona
- Inventors: Marvin J. Slepian
- Web page: https://patentgrep.com/patent/US11298290B2

## CPC

- A61B 5/1107: {Measuring contraction of parts of the body, e.g. organ or muscle}
- A61H 31/005: {with feedback for the user}
- A61B 5/11: Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb {(A61B5/1038 takes precedence; motion detection to correct for motion artifacts in physiological signals A61B5/721)}
- A61B 5/318: Heart-related electrical modalities, e.g. electrocardiography [ECG]
- A61H 99/00: Subject matter not provided for in other groups of this subclass
- G09B 19/003: {Repetitive work cycles; Sequence of movements}
- G16H 20/30: relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
- G16H 40/67: for remote operation
- A61B 5/01: Measuring temperature of body parts {; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue} (clinical contact thermometers G01K13/20)
- A61B 5/0205: Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
- A61B 5/1135: {by monitoring thoracic expansion}
- A61B 5/14542: {for measuring blood gases (A61B5/14551 takes precedence)}
- A61B 5/4833: {Assessment of subject's compliance to treatment}
- A61B 5/4836: {Diagnosis combined with treatment in closed-loop systems or methods (A61B5/0036 takes precedence)}
- A61B 2562/0219: Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
- A61H 2201/501: connected to external computer devices or networks
- A61H 2201/5043: Displays
- A61H 2201/5061: Force sensors
- A61H 2201/5071: Pressure sensors
- A61H 2201/5079: Velocity sensors
- A61H 2201/5084: Acceleration sensors
- A61H 2201/5092: Optical sensor
- A61H 2230/04: Heartbeat characteristics, e.g. E.G.C., blood pressure modulation
- A61H 2230/207: partial O2-value
- A61H 2230/40: Respiratory characteristics
- A61H 2230/50: Temperature
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61H: PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY (electrotherapy, magnetotherapy, radiation therapy or ultrasound therapy A61N)
- G09B: EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS (devices for psychotechnics or for testing reaction times A61B5/16; games, sports, amusements A63; projectors, projector screens G03B)
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA

## Abstract

Wearable sensors that measure one or more parameters such as pressure, force, acceleration, or skin temperature, are used to measure, record, display and monitor the efficacy of therapeutic maneuvers applied to a subject by an operator. Systems and methods for assessing the physiological efficacy of therapeutic maneuvers performed by an operator on a subject in need thereof, and provide a way to guide subsequent therapeutic maneuvers toward optimal outcome. In some embodiments, the systems and methods measure, record, and display physiological parameters of an operator and/or subject during application of cardiopulmonary resuscitation (CPR).

## Claims

### Claim 1

A system adapted to monitor chest compressions of cardiopulmonary resuscitation (CPR), comprising:
at least one sensor adapted to be coupled to a subject's chest and configured for measuring one or more of displacement, velocity, acceleration, rotation, and applied force;
an analysis, storage, and display unit having a processor and a memory storing machine readable instructions configured to direct the processor to:
read the at least one sensor;
determine parameters derived from readings of the at least one sensor; and
display the parameters derived from the readings of the at least one sensor. the parameters including measurements of vertical depth of CPR compressions, rate of CPR compression, and lateral movements of the subject's chest.

### Claim 2 (depends on 1)

The system of claim 1 wherein the at least one sensor comprises a microphone and the parameters further include breath rate and depth of the subject.

### Claim 3 (depends on 2)

The system of claim 2, further comprising a telemetry system of nested loops wherein the sensor communicates with one or more of an implanted device of the subject, a wearable device, a free-standing electronic communication device, and a server accessible over the internet.

### Claim 4 (depends on 2)

The system of claim 2, the sensor comprising a three- dimensional (3D) accelerometer selected from the group consisting of a 3D accelerometer configured for attachment to a center of a sternum of a subject and a pair of 3D accelerometers including a 3D accelerometer configured for attachment over a sternal notch of a subject, and a 3D accelerometer configured for attachment over a xiphoid process of the subject.

### Claim 5 (depends on 4)

The system of claim 4, at least one of the at least one sensor further comprising a short range digital radio adapted to link to a short range digital radio of the analysis and display unit.

### Claim 6 (depends on 5)

The system of claim 5, the parameters comprising one or more of dimensions, velocity, acceleration, rotation, frequency, regularity, periodicity, intensity, pressure of movement, pressure generated by movement, and shear of movement.

### Claim 7 (depends on 6)

The system of claim 6, further comprising a signature database stored within the memory and including at least one signature corresponding to a prior or ideal CPR session, the memory further comprising machine readable instructions configured to direct the processor to compare a signature derived from a present CPR session to the at least one signature corresponding to a prior or guideline CPR session to provide immediate feedback to a CPR operator.

### Claim 8 (depends on 7)

The system of claim 7, further comprising a microphone, and wherein the code includes machine readable instructions to determine presence of airflow from data received from the microphone.

### Claim 9 (depends on 7)

The system of claim 7, the at least one sensor further comprising gyroscopic sensors.

### Claim 10 (depends on 7)

The system of claim 7, wherein the sensors further comprise sensors comprising accelerometers configured for attachment to an operator performing CPR, and the analysis and display unit is configured to determine an extent of the operator's use of arm muscles or other musculature to perform compressions.

### Claim 11 (depends on 7)

The system of claim 7, wherein the sensor comprises an array of sensors configured with a garment.

### Claim 12 (depends on 7)

The system of claim 7, further comprising at least one physiologic sensor, the at least one physiologic sensor including one or more of an optical oxygen saturation sensor, a pulse detection device, and a temperature measuring device, and wherein the code includes machine readable instructions to display one or more of determined oxygen saturation, detected pulse or perfusion, and rewarming.

### Claim 13 (depends on 12)

The system of claim 12, wherein the sensors further comprise a flow detection sensor adapted for placement over the point of maximum intensity (Cardiac PMI) and/or a carotid, femoral or other arterial pulse point of the subject.

### Claim 14 (depends on 12)

The system of claim 12, wherein the analysis and display unit further comprises code for communicating signatures of CPR sessions to a database server.

### Claim 15 (depends on 12)

The system of claim 12, further comprising an electrocardiographic sensor and wherein the code includes machine readable instructions to indicate on the display whether the subject has a normal ECG or configuration pattern or has an abnormal cardiac condition.

### Claim 16 (depends on 15)

The system of claim 15, further comprising a microphone, wherein the code includes machine readable instructions to determine presence of airflow in the subject's chest from data received from the microphone.

### Claim 17 (depends on 16)

The system of claim 16, wherein the sensors further comprise sensors comprising accelerometers configured for attachment to an operator performing CPR and linked by short range digital radio to the analysis and display unit, and the analysis and display unit is configured to determine an extent of the operator's use of hand, forearm, arm, and torso muscles to perform compressions.

### Claim 18 (depends on 17)

The system of claim 17, wherein the sensors further comprise a blood flow detection sensor adapted for placement over one of a point of maximum intensity (Cardiac PMI), a carotid, femoral or other arterial pulse point of the subject.

### Claim 19 (depends on 18)

The system of claim 18, wherein the analysis and display unit further comprises code for uploading the signature derived from a present CPR session to a database server for entry into a database.

### Claim 20 (depends on 19)

The system of claim 19, further comprising data-mining code configured to identify characteristics of successful and unsuccessful resuscitations by analyzing a plurality of signatures stored in the database.

### Claim 21 (depends on 18)

The system of claim 18, the flow detection sensor being selected from the group consisting of ultrasonic, plethysmographic, optical, and temperature sensors.

### Claim 22

A method of monitoring cardiopulmonary resuscitation (CPR), comprising:
receiving, over a short range digital radio, sensor data including accelerometer data from at least one three-dimensional accelerometer configured for attachment to a subject, the accelerometer data indicative of accelerations of a sternum of the subject; and
determining vertical and lateral movements of the sternum from the accelerometer data, and displaying parameters derived from the movements of the sternum including depth and rate of CPR compressions and lateral motions.

### Claim 23 (depends on 22)

The method of claim 22, further comprising determining a motion signature from the sensor data and comparing the motion signature to desirable motion signatures of CPR.

### Claim 24 (depends on 23)

The method of claim 23, wherein the sensor data includes data from a bloodflow sensor and the parameters displayed further comprise a measure of blood flow.

### Claim 25 (depends on 23)

The method of claim 23, wherein the sensor data includes data from a pulse oximeter sensor and the parameters displayed further comprise blood oxygenation.

### Claim 26 (depends on 22)

The method of claim 22, wherein the parameters are displayed in real time as feedback to an operator to assist the operator to perform more effective CPR.