# US 11,298,262 B2 · Ophthalmic device for drug delivery

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- Number: US 11,298,262 B2
- Document ID: US11298262B2
- Status: Granted
- Kind: B2
- Application number: 16/516,356
- Filed: 2019-07-19
- Published: 2020-01-23
- Granted: 2022-04-12
- Earliest claimed: 2018-07-23
- Assignees: The Regents of the University of Colorado, a body corporate; SpyGlass Pharma, Inc.
- Applicants: The Regents of the University of Colorado, a body corporate; SpyGlass Pharma, Inc.
- Inventors: Malik Y. Kahook; Glenn Sussman; Craig Alan Cable, II
- Web page: https://patentgrep.com/patent/US11298262B2

## CPC

- A61F 2/1613: {having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus}
- A61F 9/0017: {implantable in, or in contact with, the eye, e.g. ocular inserts}
- A61F 2/147: {Implants to be inserted in the stroma for refractive correction, e.g. ring-like implants}
- A61F 2/15: {Implant having one or more holes, e.g. for nutrient transport, for facilitating handling}
- A61F 2/16: Intraocular lenses
- A61F 2/1694: {Capsular bag spreaders therefor}
- A61F 2002/1681: {having supporting structure for lens, e.g. haptics}
- A61F 2002/1683: {having filiform haptics}
- A61F 2002/1689: {having plate-haptics}
- A61F 2002/169: {Surrounding optic}
- A61F 2002/16905: {Having means on lens to reduce overall dimension of lens for insertion into small incision}
- A61F 2002/1699: {Additional features not otherwise provided for}
- A61F 2220/0025: Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F 2220/0033: made by longitudinally pushing a protrusion into a complementary-shaped recess, e.g. held by friction fit
- A61F 2230/0065: toroidal, e.g. ring-shaped, doughnut-shaped
- A61F 2250/0063: Nested prosthetic parts
- A61F 2250/0067: Means for introducing or releasing pharmaceutical products into the body
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)

## Abstract

An ophthalmic implant for drug delivery. The implant includes a primary intracapsular device coupled to a secondary device, wherein, when implanted in a patient's eye, the primary intracapsular device is held in place by the patient's capsular bag and the secondary device is held in place by the primary intracapsular device. The implant may be inserted in the eye by injecting the primary intracapsular device into the eye either before or after attaching the secondary device to the primary intracapsular device, and subsequently positioning the joined secondary device and primary intracapsular device with the primary intracapsular device held in place by the patient's capsular bag and the secondary device held in place by the primary intracapsular device. The secondary device may be designed to hold a tertiary device that can be implanted and attached at the time of surgery or anytime postoperatively.

## Claims

### Claim 1

An ophthalmic implant comprising:
a multi-part IOL assembly comprising a primary device (23) comprising an IOL (22) and a secondary device comprising a first drug delivery device (30);
wherein:
said IOL (22) comprising a lens (24), a tab (26), and a haptic (28);
said tab (26) extending from the IOL (22), and said tab (26) configured to engage the first drug delivery device (30);
said haptic (28) extending radially outwardly from the lens (24), such that said haptic (28) is configured to hold the IOL (22) in place within a capsular bag of a patient's eye;
said first drug delivery device (30) comprises a ring configured for a mechanical fit on the tab (26); and
in an assembled configuration, the first drug delivery device (30) is engaged in said mechanical fit with the tab (26) to secure the first drug delivery device (30) to the IOL (22) such that the tab (26) extends from the IOL (22) through a hole in the first drug delivery device (30) to establish said mechanical fit on the tab (26).

### Claim 2 (depends on 1)

The ophthalmic implant of claim 1, wherein:
the first drug delivery device (30) comprises a drug pad integrated into the first drug delivery device (30).

### Claim 3 (depends on 1)

The ophthalmic implant of claim 1, wherein:
the first drug delivery device (30) is further configured to comprise a drug pad.

### Claim 4 (depends on 1)

The ophthalmic implant of claim 1, wherein:
the first drug delivery device (30) further comprises a refillable reservoir.

### Claim 5 (depends on 1)

The ophthalmic implant of claim 1, further comprising:
a second drug delivery device (39) configured for attachment to the first drug delivery device (30).

### Claim 6 (depends on 1)

The ophthalmic implant of claim 1, wherein:
the haptic (28) extending radially outwardly from the lens (24) extends outwardly in a plane of the lens.

### Claim 7 (depends on 1)

The ophthalmic implant of claim 1, wherein:
the IOL (22) has an anterior side (24) and is configured for placement into the eye of a patient with said anterior side (24) disposed anteriorly in the eye of the patient; and
the tab (26) extends from the anterior side (24) of the IOL (22).