# US 11,298,213 B2 · Ceramic bodies having antimicrobial properties and methods of making the same

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- Number: US 11,298,213 B2
- Document ID: US11298213B2
- Status: Granted
- Kind: B2
- Application number: 16/167,950
- Filed: 2018-10-23
- Published: 2019-04-25
- Granted: 2022-04-12
- Earliest claimed: 2017-10-23
- Assignees: James R. Glidewell Dental Ceramics, Inc.
- Applicants: James R. Glidewell Dental Ceramics, Inc.
- Inventors: Jae Won Kim
- Web page: https://patentgrep.com/patent/US11298213B2

## CPC

- A61C 8/0013: {with a surface layer, coating}
- A61C 8/0012: {characterised by the material or composition, e.g. ceramics, surface layer, metal alloy (use of specific materials A61K6/00)}
- A61C 8/0018: {characterised by the shape}
- A61C 13/083: Porcelain or ceramic teeth {(A61C13/081 takes precedence; preparations A61K6/80)}
- A61K 6/58: specially adapted for dental implants
- A61K 6/802: comprising ceramics
- A61K 6/818: comprising zirconium oxide
- A61K 6/824: comprising transition metal oxides
- A61L 27/34: Macromolecular materials
- A61L 27/427: {of other specific inorganic materials not covered by A61L27/422 or A61L27/425}
- C04B 41/4535: {applied as a solution, emulsion, dispersion or suspension}
- A61C 5/73: Composite crowns
- A61C 8/005: {Connecting devices for joining an upper structure with an implant member, e.g. spacers}
- A61C 8/008: {Healing caps or the like}
- A61C 13/0022: {Blanks or green, unfinished dental restoration parts}
- A61K 6/50: Preparations specially adapted for dental root treatment
- A61K 6/56: Apical treatment
- A61L 2430/12: for dental implants or prostheses
- C08G 77/58: Metal-containing linkages
- C09D 183/14: in which at least two but not all the silicon atoms are connected by linkages other than oxygen atoms (C09D183/10 takes precedence)
- A61C: DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE (non-driven toothbrushes A46B; {tongue scrapers A61B17/24;} preparations for dentistry A61K6/00; preparations for cleaning the teeth or mouth A61K8/00, A61Q11/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- C04B: LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE {(roofing granules E04D7/005)}; CERAMICS (devitrified glass-ceramics C03C10/00); REFRACTORIES; TREATMENT OF NATURAL STONE
- C08G: MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C09D: COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR (cosmetics A61K; processes for applying liquids or other fluent materials to surfaces, in general, B05D; staining wood B27K5/02; glazes or vitreous enamels C03C; natural resins, French polish, drying-oils, driers, turpentine, per se, C09F; polishing compositions other than French polish, ski waxes C09G; adhesives or use of materials as adhesives C09J; materials for sealing or packing joints or covers C09K3/10; materials for stopping leaks C09K3/12; processes for the electrolytic or electrophoretic production of coatings C25D)

## Abstract

A method for making a ceramic body comprised of a ceramic material having an inhibitory effect on bacterial growth is provided. A dental prosthesis may be made of a ceramic material that comprises a molybdenum-containing component on a portion of the prosthesis that contacts the gingival surface of a patient. In one method, a porous zirconia ceramic structure is shaped in the form of a dental prosthesis, and then infiltrated with a molybdenum-containing composition, before sintering to densify the ceramic structure.

## Claims

### Claim 1

A method of making a sintered ceramic dental prosthesis for restoring dentition of a patient that inhibits bacterial growth, comprising
a. obtaining a porous ceramic body comprising a shape of a dental prosthesis,
b. obtaining a liquid molybdenum-containing composition comprising from 0.015 wt % to 5 wt % of a molybdenum-containing component, based on the weight of the molybdenum-containing composition,
c. infiltrating the liquid molybdenum-containing composition into a first portion of the porous ceramic body that corresponds to a portion of the sintered ceramic body that contacts a gingival surface of the patient, and
d. sintering the infiltrated porous zirconia ceramic to form the sintered ceramic dental prosthesis.

### Claim 2 (depends on 1)

The method of claim 1, wherein the liquid molybdenum-containing composition is an aqueous solution.

### Claim 3 (depends on 1)

The method of claim 1, wherein the liquid molybdenum-containing composition comprises a resin.

### Claim 4 (depends on 1)

The method of claim 1, wherein the molybdenum-containing component comprises a molybdenum-containing salt.

### Claim 5 (depends on 1)

The method of claim 1, wherein the molybdenum-containing component comprises molybdenum (V) chloride (MoCl5).

### Claim 6 (depends on 1)

The method of claim 1, wherein the liquid molybdenum-containing composition comprises from 0.015 wt % to 3 wt % of the molybdenum-containing component, based on the weight of the molybdenum-containing composition.

### Claim 7 (depends on 1)

The method of claim 1, wherein the liquid molybdenum-containing composition comprising 0.015 wt % to less than 0.1 wt % of the molybdenum-containing component, based on the weight of the molybdenum-containing composition.

### Claim 8 (depends on 1)

The method of claim 1, wherein the dental prosthesis is an implant, and the porous zirconia ceramic body is fully infiltrated with the liquid molybdenum-containing composition.

### Claim 9 (depends on 1)

The method of claim 1, wherein the dental prosthesis is a crown, and the first portion corresponds to an intaglio surface or a margin of the sintered ceramic dental prosthesis.

### Claim 10 (depends on 1)

The method of claim 1, wherein the dental prosthesis is a crown, and the first portion corresponds to a cervical third region of the sintered ceramic dental prosthesis.

### Claim 11 (depends on 1)

The method of claim 1, wherein the dental prosthesis is an implant abutment and the first portion corresponds to a subgingival portion when the sintered ceramic dental restoration is installed in the mouth of a user.

### Claim 12 (depends on 1)

The method of claim 1, wherein the porous ceramic body comprises an yttria-stabilized zirconia.

### Claim 13 (depends on 1)

The method of claim 1, wherein the sintering step is performed at a sintering temperature greater than 800° C.

### Claim 14 (depends on 1)

The method of claim 1, wherein the porous body comprises a second portion that is not infiltrated with the liquid molybdenum-containing composition, and the second portion corresponds to a vestibular surface of an incisal region of the sintered dental restoration.