# US 11,297,873 B2 · Ketogenic nutritional compositions > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,297,873 B2 - Document ID: US11297873B2 - Status: Granted - Kind: B2 - Application number: 16/331,478 - Filed: 2017-09-05 - Published: 2019-06-27 - Granted: 2022-04-12 - Earliest claimed: 2016-09-13 - Assignees: Abbott Laboratories - Applicants: Abbott Laboratories - Inventors: Sean Garvey; Stephen Demichele; Roger Tyre; Eric Torgerson; Steven Hertzler - Web page: https://patentgrep.com/patent/US11297873B2 ## CPC - A23L 33/40: {Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula} - A23L 33/00: Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof - A23L 33/115: Fatty acids or derivatives thereof; Fats or oils - A23L 33/185: Vegetable proteins - A23L 33/19: Dairy proteins - A23L 33/30: {Dietetic or nutritional methods, e.g. for losing weight (A23L33/10 takes precedence)} - A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs - A23V 2200/332: Promoters of weight control and weight loss - A23V 2200/3322: Low carb - reduced carbohydrate content - A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B) - A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION ## Abstract A nutritional composition comprises fat, protein and carbohydrate such that the fat provides from about 60 to about 90% of the total calories of the composition, the protein provides from about 10 to about 30% of the total calories of the composition, and the carbohydrate provides from about 0.1 to about 15% of the total calories of the composition, and the composition comprises from about 0.01 to about 10 wt % beta-hydroxy-beta-methylbutyrate (HMB). A method of achieving or sustaining metabolic ketosis in an individual comprises administering the nutritional composition to the individual. A method of maintaining lean body mass and muscle strength in an individual during dietary ketosis comprises administering the nutritional composition to the individual. ## Claims ### Claim 1 An emulsified liquid nutritional composition, comprising fat, protein and carbohydrate, wherein the fat provides from about 60 to about 90% of the total calories of the composition, the protein provides from about 10 to about 30% of the total calories of the composition, and the carbohydrate provides from about 0.1 to about 15% of the total calories of the composition, wherein the composition comprises from about 45 to about 80 wt % fat, from about 20 to about 45 wt % protein, and from about 0.1 to about 15 wt % carbohydrate, based on the combined weight of the fat, protein and carbohydrate, wherein the weight ratio of fat to protein is in the range of about 1.1:1 to about 4.0:1, and wherein the composition comprises from about 0.1% to about 5.0% wt % beta-hydroxy-beta-methylbutyrate (HMB). ### Claim 2 (depends on 1) The nutritional composition of claim 1, wherein the fat provides from about 70 to about 80% of the total calories of the composition, the protein provides from about 15 to about 25% of the total calories of the composition, and the carbohydrate provides from about 1 to about 10% of the total calories of the composition. ### Claim 3 (depends on 1) The nutritional composition of claim 1, wherein the composition comprises from about 50 to about 70 wt % fat, from about 25 to about 40 wt % protein, and from about 0.1 to about 15 wt % carbohydrate, based on the combined weight of the fat, protein and carbohydrate. ### Claim 4 (depends on 1) The nutritional composition of claim 1, wherein a 325 ml serving of the composition provides from about 1 to about 3 grams HMB. ### Claim 5 (depends on 1) The nutritional composition of claim 1, wherein the HMB is provided as an ester of HMB, a lactone of HMB, a free acid of HMB or a salt of HMB. ### Claim 6 (depends on 5) The nutritional composition of claim 5, wherein the HMB is provided as calcium HMB monohydrate. ### Claim 7 (depends on 1) The nutritional composition of claim 1, wherein a source of the fat comprises whole egg powder, egg yolk powder, egg white powder, coconut milk, coconut oil, fractionated coconut oil, soy oil, corn oil, butter oil, olive oil, safflower oil, high oleic safflower oil, medium chain triglycerides, sunflower oil, high oleic sunflower oil, palm oil, palm kernel oil, palm olein, canola oil, algae oil, borage oil, marine oil, fish oil, cottonseed oil, a structured lipid, any of said oils in powder form, or a combination of two or more thereof. ### Claim 8 (depends on 7) The nutritional composition of claim 7, wherein the source of the fat comprises whole egg powder, butter powder, and coconut milk powder. ### Claim 9 (depends on 7) The nutritional composition of claim 7, wherein the source of the fat comprises a structured lipid. ### Claim 10 (depends on 7) The nutritional composition of claim 7, wherein the source of the fat comprises MCT oil. ### Claim 11 (depends on 10) The nutritional composition of claim 10, wherein the source of the fat further comprises one or more additional oils selected from the group consisting of butter oil, high oleic safflower oil, high oleic sunflower oil, coconut oil and a structured lipid. ### Claim 12 (depends on 1) The nutritional composition of claim 1, wherein a source of the protein comprises whole egg powder, egg yolk powder, egg white powder, whey protein, whey protein concentrate, whey protein isolate, whey protein hydrolysate, acid casein, casein protein isolates, sodium caseinate, calcium caseinate, potassium caseinate, casein hydrolysate, milk protein concentrate, milk protein isolate, milk protein hydrolysate, nonfat dry milk, whole cow's milk, partially or completely defatted milk, coconut milk, soy protein concentrate, soy protein isolate, soy protein hydrolysate, pea protein concentrate, pea protein isolate, pea protein hydrolysate, rice protein concentrate, rice protein isolate, rice protein hydrolysate, collagen protein, or a combination of two or more thereof. ### Claim 13 (depends on 1) The nutritional composition of claim 1, wherein a source of the carbohydrate comprises maltodextrin, hydrolyzed or modified starch, hydrolyzed or modified cornstarch, glucose polymer, corn syrup, corn syrup solids, rice-derived carbohydrate, sucrose, glucose, fructose, lactose, honey, sugar alcohol, artificial sweetener, or a combination of two or more thereof. ### Claim 14 (depends on 1) The nutritional composition of claim 1, further comprising polyphenol. ### Claim 15 (depends on 1) The nutritional composition of claim 1, further comprising sodium and potassium. ### Claim 16 (depends on 1) A method of achieving or sustaining metabolic ketosis in an individual, comprising administering to the individual the nutritional composition of claim 1. ### Claim 17 (depends on 1) A method of maintaining lean body mass and muscle strength in an individual during dietary ketosis, comprising administering to the individual the nutritional composition of claim 1. ### Claim 18 (depends on 1) The nutritional composition of claim 1, wherein the composition comprises from about 45 to about 65 wt % fat, from about 25 to about 40 wt % protein, and from about 1 to about 10 wt % carbohydrate, based on the combined weight of the fat, protein and carbohydrate. ### Claim 19 (depends on 1) The nutritional composition of claim 1, wherein the weight ratio of fat to protein is in the range of about 1.5:1 to about 3.5:1. ### Claim 20 (depends on 1) The nutritional composition of claim 1, wherein a source of the protein comprises whey protein, whey protein concentrate, whey protein isolate, whey protein hydrolysate, acid casein, casein protein isolates, sodium caseinate, calcium caseinate, potassium caseinate, casein hydrolysate, milk protein concentrate, milk protein isolate, milk protein hydrolysate, nonfat dry milk, whole cow's milk, partially or completely defatted milk, coconut milk, or a combination of two or more thereof. ### Claim 21 (depends on 1) The nutritional composition of claim 1, wherein the only carbohydrate that is included in the nutritional composition is that inherent in the sources of fat and protein. ### Claim 22 (depends on 1) The nutritional composition of claim 1, wherein a source of fat comprises a structured lipid comprising an interesterified mixture of medium and long chain fatty acids of medium chain triglyceride oil and canola oil, a source of the protein comprises milk protein concentrate, milk protein isolate, milk protein hydrolysate, nonfat dry milk, whole cow's milk, partially or completely defatted milk, coconut milk, or a combination of two or more thereof, and the only carbohydrate that is included in the nutritional composition is that inherent in the sources of fat and protein.