# US 11,297,869 B2 · Botanical modulator of metabolic disorders

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- Number: US 11,297,869 B2
- Document ID: US11297869B2
- Status: Granted
- Kind: B2
- Application number: 17/158,693
- Filed: 2021-01-26
- Published: 2021-06-24
- Granted: 2022-04-12
- Earliest claimed: 2018-08-31
- Assignees: Innophos, Inc.
- Applicants: Innophos, Inc.
- Inventors: Jatinder Rana; Kylie Mitchell
- Web page: https://patentgrep.com/patent/US11297869B2

## CPC

- A23L 33/135: Bacteria or derivatives thereof, e.g. probiotics
- A61K 36/22: Anacardiaceae (Sumac family), e.g. smoketree, sumac or poison oak
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A61P 3/04: Anorexiants; Antiobesity agents
- A61P 3/06: Antihyperlipidemics
- A61P 3/10: for hyperglycaemia, e.g. antidiabetics
- A61P 3/14: for calcium homeostasis (vitamin D A61P3/02; parathyroid hormones A61P5/18; calcitonin A61P5/22; osteoporosis A61P19/10; bone metastasis A61P35/04)
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

Plant-based inhibitors of MMP-9 that also function as PPAR-γ agonists, and the use of such plant-based inhibitors/agonists in modulating metabolic disorders is disclosed. The plant-based inhibitor/agonist is at least an extract obtained from the genus Anacardium.

## Claims

### Claim 1

A method of modulating one or more metabolic disorders in a subject comprising:
administering a composition comprising a botanical extract of the testa of Anacardium occidentale L.,
wherein the botanical extract has been standardized to a catechin content of about 15.0 w/w % or greater, based on total weight of the extract, and
wherein the botanical extract is present in the composition in an amount of from about 15.0 μg/mL to about 250.0 μg/mL.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the composition is a dietary supplement.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the dietary supplement is in solid dosage form and the carrier is chosen from gelatin, starch, magnesium stearate, talc, gums, silicon dioxide, stearic acid, cellulose and combinations thereof.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the composition is effective in inhibiting the expression of MMP-9.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the composition exhibits PPAR-γ agonist activity.