# US 11,297,852 B2 · Method for treatment or prevention of gill disease

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- Number: US 11,297,852 B2
- Document ID: US11297852B2
- Status: Granted
- Kind: B2
- Application number: 16/437,635
- Filed: 2019-06-11
- Published: 2019-10-24
- Granted: 2022-04-12
- Earliest claimed: 2015-08-14
- Assignees: Nutreco IP Assets B.V.
- Applicants: Nutreco IP Assets B.V.
- Inventors: Julia Elizabeth Mullins; Charles McGurk; Øyvind Røn
- Web page: https://patentgrep.com/patent/US11297852B2

## CPC

- A23K 20/142: Amino acids; Derivatives thereof
- A23K 20/158: Fatty acids; Fats; Products containing oils or fats
- A23K 20/174: Vitamins
- A23K 20/20: Inorganic substances, e.g. oligoelements
- A23K 40/25: by extrusion
- A23K 50/80: for aquatic animals, e.g. fish, crustaceans or molluscs
- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A61P 33/04: Amoebicides
- A23K 20/147: Polymeric derivatives, e.g. peptides or proteins
- A23K 20/30: {Oligoelements}
- Y02A 40/81: Aquaculture, e.g. of fish
- A23K: FODDER
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

## Abstract

Composition for treatment of mucus on fish gills for a therapeutic or a prophylactic treatment of an amoebic gill disease in fish, where the composition comprises an extruded fish feed supplemented with arginine; said fish feed comprising protein, binder, fat, vitamins and minerals; and a total arginine content of the fish feed is at least 3.0% (wt/wt) of a total feed weight.

## Claims

### Claim 1

A method of increasing a mucus viscosity of a fish in need thereof, comprising determining that the fish is in need of increased mucus viscosity, and providing an extruded fish feed to the fish in need thereof, wherein the extruded fish feed comprises a total arginine content of at least 3.0% (wt/wt) of total feed weight.

### Claim 2 (depends on 1)

The method of claim 1, wherein the extruded fish feed comprises protein, binder, fat, vitamins, and minerals.

### Claim 3 (depends on 1)

The method of claim 1, wherein the fish comprises a salmonid fish.

### Claim 4 (depends on 3)

The method of claim 3, wherein the salmonid fish comprises at least one of rainbow trout or Atlantic salmon.

### Claim 5

A method of increasing a polysaccharide concentration in the mucus of a fish in need thereof, comprising determining that the fish is in need of increased polysaccharide concentration in the mucus, and providing an extruded fish feed to the fish in need thereof, wherein the extruded fish feed comprises a total arginine content of at least 3.0% (wt/wt) of total feed weight.

### Claim 6 (depends on 5)

The method of claim 5, wherein the extruded fish feed comprises protein, binder, fat, vitamins, and minerals.

### Claim 7 (depends on 5)

The method of claim 5, wherein the fish comprises a salmonid fish.

### Claim 8 (depends on 7)

The method of claim 7, wherein the salmonid fish comprises at least rainbow trout or Atlantic salmon.

### Claim 9

A method of increasing a lysozyme concentration in the mucus of a fish in need thereof, comprising determining that the fish is in need of increased lysozyme concentration in the mucus, and providing an extruded fish feed to the fish in need thereof, wherein the extruded fish feed comprises a total arginine content of at least 3.0% (wt/wt) of total feed weight.

### Claim 10 (depends on 9)

The method of claim 9, wherein the extruded fish feed comprises protein, binder, fat, vitamins, and minerals.

### Claim 11 (depends on 9)

The method of claim 9, wherein the fish comprises a salmonid fish.

### Claim 12 (depends on 11)

The method of claim 11, wherein the salmonid fish comprises at least rainbow trout or Atlantic salmon.