# US 11,297,835 B2 · Aqueous compositions of perillic acid compounds > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,297,835 B2 - Document ID: US11297835B2 - Status: Granted - Kind: B2 - Application number: 16/072,336 - Filed: 2016-12-22 - Published: 2019-01-31 - Granted: 2022-04-12 - Earliest claimed: 2016-01-29 - Assignees: BRAIN Biotech AG - Applicants: B.R.A.I.N. Biotechnology Research and Information Network AG - Inventors: Jessica Rehdorf; Alice Kleber - Web page: https://patentgrep.com/patent/US11297835B2 ## CPC - A01N 37/08: containing carboxylic groups or thio analogues thereof, directly attached by the carbon atom to a cycloaliphatic ring; Derivatives thereof - A23L 2/52: Adding ingredients (adding preservatives A23B70/10) - A23L 33/10: using additives (addition of substantially indigestible substances A23L33/21) - A61K 8/062: {Oil-in-water emulsions} - A61K 8/064: {Water-in-oil emulsions, e.g. Water-in-silicone emulsions} - A61K 8/36: Carboxylic acids; Salts or anhydrides thereof - A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60) - A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers - A61K 47/36: Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin - A61P 17/00: Drugs for dermatological disorders - A61P 17/10: Anti-acne agents - A61P 31/04: Antibacterial agents - A61P 31/10: Antimycotics - A61Q 19/00: Preparations for care of the skin - A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs - A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS - A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS - A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION ## Abstract The present invention relates to compositions of perillic acid compounds, therapeutic and non-therapeutic uses of the compounds and compositions as well as a method of preparing the composition. ## Claims ### Claim 1 A composition comprising: at least one perillic acid compound, selected from the group consisting of perillic acid, and one or more salts of perillic acid, and water, wherein the composition has a pH in the range of from 2.5 to 6.5, wherein the perillic acid compound is present in an amount from about 0.001% (w/v) to about 0.2% (w/v) so that the composition is capable of maintaining the total amount of Lactobacillus sp. present in the composition below 1,000 cfu/mL after 28 days at 22-25° C. ### Claim 2 (depends on 1) The composition according to claim 1, comprising the perillic acid compound in an amount of at least 0.01% w/v. ### Claim 3 (depends on 1) The composition according to claim 1, wherein the perillic acid compound comprises a salt of perillic acid, wherein the salt comprises the ammonium salt, the alkali metal salt or the alkaline metal salt. ### Claim 4 (depends on 1) The composition according to claim 1, wherein the perillic acid compound comprises sodium perillate, potassium perillate, ammonium perillate, calcium perillate, magnesium perillate, and mixtures thereof. ### Claim 5 (depends on 1) The composition according to claim 1, wherein the pH is at least 3. ### Claim 6 (depends on 1) The composition according to claim 1, wherein the pH is from 4.5 to 6.5. ### Claim 7 (depends on 1) The composition according to claim 1, wherein the amount of water is at least 10% by weight relative to the total amount of the composition. ### Claim 8 (depends on 1) The composition according to claim 1, wherein the amount of water is at least 30% by weight relative to the total amount of the composition. ### Claim 9 (depends on 1) The composition according to claim 1, wherein the perillic acid compound is used in the form of its R-enantiomer, its S-enantiomer or any mixture thereof, including racemic mixtures. ### Claim 10 (depends on 1) The composition according to claim 1, wherein the composition comprises a foodstuff, food packaging, beverage, animal food, medicinal product, pharmaceutical product, cosmetic product, household product, plant protection, industrial or technical product. ### Claim 11 (depends on 1) The composition according to claim 1, wherein the composition comprises limonene in a concentration of less than 10 mM. ### Claim 12 (depends on 1) The composition according to claim 1, wherein the composition does not comprise any limonene in detectable amounts. ### Claim 13 (depends on 1) The composition according to claim 1, wherein the composition additionally comprises at least one antimicrobial compound. ### Claim 14 (depends on 1) The composition according to claim 1, wherein the range of said perillic acid is from about 0.000977% w/v to about 0.0099% w/v. ### Claim 15 (depends on 2) The composition according to claim 2, wherein the range of said perillic acid is from about 0.000977% w/v to about 0.0099% w/v. ### Claim 16 (depends on 5) The composition according to claim 5, wherein the range of said perillic acid is from about 0.000977% w/v to about 0.0099% w/v. ### Claim 17 (depends on 6) The composition according to claim 6, wherein the range of said perillic acid is from about 0.000977% w/v to about 0.0099% w/v.