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US 11,292,805 B2Granted
Preparation method of a cyclic phosphonate compound
AssigneeGannex Pharma Co., Ltd.
InventorsJinzi Jason Wu, Bailing Yang, Bin Liang
Life of this patent
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Abstract
A method for preparing the cyclic phosphonate compound of Formula I is described. The method significantly improves the stereoselectivity of the compound with the required configuration.
Claims14
A method for preparing a cyclic phosphonate compound shown in Formula I,
- comprising the steps of:
- (1) reacting a compound of Formula 9 with a chlorinating agent to obtain a phosphonyl chloride intermediate of Formula 11,
- and dissolving the phosphonyl chloride intermediate of Formula 11 in a first organic solvent to form a solution of Formula 11;
- (2) dissolving a compound of Formula 10 in a second organic solvent to form a solution of Formula 10
- adding sequentially a Lewis acid and then an alkali to the solution of Formula 10 to form a reaction solution, wherein the Lewis acid is selected from the group consisting of TiCl4, SnCl4, FeCl3 and combinations thereof;
- and
- (3) adding the reaction solution of step (2) into the solution of Formula 11 to produce the cyclic phosphonate compound of Formula I.
4 more elements
Dependencies are inferred from the claim text.