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US 11,291,735 B2Granted
Drug delivery system based on JCV-VLP
AssigneeLife Science Inkubator Betriebs GmbH & Co. KG
InventorsVictoria Demina, Heiko Manninga, Armin Götzke, Alexander Glassmann
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Abstract
The invention relates to VLP derived from human polyoma virus loaded with a drug (cargo) as a drug delivery system for transporting said drug into the CNS, in particular of living humans.
Claims12
A method of treating a central nervous system (CNS) disease or a neurological, neuronal or neurodegenerative disorder, the method comprising:
- intravenously administering a drug delivery system composed of virus-like particles (VLP) loaded with a drug into a subject in need thereof, wherein said subject has a physiologically intact blood-brain barrier (BBB),
- wherein the VLP cross the blood-brain barrier (BBB) of the subject together with the drug,
- wherein the VLP are composed of VP1 comprising an amino acid sequence which is at least 80% identical to the amino acid sequence according to SEQ ID NO:
- 1 over its entire length, and
- wherein in said method, said drug delivery system does not further contain, and said subject is not administered, an additive that decreases the integrity of, or increases the permeability of, the BBB.
2 more elements
Dependencies are inferred from the claim text.