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US 11,286,500 B2Granted
Recombinant Orf virus vector
AssigneeEberhard Karls Universität Tübingen Medizinische Fakultät
InventorsHanns-Joachim Rziha, Ralf Amann
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Abstract
A nucleic acid molecule can code for an Orf virus vector promoter. A recombinant Orf virus vector can be included in a cell. The nucleic acid molecule, the vector and/or the cell can be included in a composition. The recombinant Orf virus vector can be used for the production of a foreign gene.
Claims19
A recombinant Orf virus (ORFV) vector, which comprises:
- (1) at least one nucleotide sequence encoding and expressing a foreign gene, and
- (2) at least one promoter controlling the expression of the nucleotide sequence,
- wherein:
- the nucleotide sequence is localized in at least one of insertion loci (IL) 1, 2 and 3, which are localized in the ORFV genome in a region selected from the group consisting of the following regions:
- IL 1
- IL 2
- IL 3
- Restriction
- HindIII
- HindIII fragment I/
- HindIII fragment G/
- fragment
- fragment C,
- J, KpnI fragment B,
- D, KpnI
- KpnI fragment
- BamHI fragment A,
- fragment B, BamHI
- G, BamHI
- EcoRI fragment A/E
- fragment A,
- fragment C/G,
- EcoRI fragment D
- EcoRI fragment B
- Gene/ORF
- 006,
- 102,
- 114,
- 007 (dUTPase),
- 103
- 115,
- 008 (G1L-Ank),
- 116,
- 009 (G2L)
- 117 (GIF)
- and
- Nucleotide
- nt 500 ± 100 to
- nt 5,210 ± 100 to
- nt 15,660 ± 100 to
- position
- nt 2,400 ± 600
- nt 7,730 ± 100
- nt 17,850 ± 100,
- and wherein the OFFV is of the strain D1701.
42 more elements
Dependencies are inferred from the claim text.