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US 11,286,233 B2Granted
Stilbene derivatives for the treatment of CNS and other disorders
AssigneeAmbient Photonics, Inc.
InventorJohn C. Warner
Life of this patent
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Abstract
The present application discloses stilbene derivative compounds and compositions, and methods for treating ocular diseases, neurological disorders and protein aggregation-related disorders in patients using the compounds and compositions as disclosed herein.
Claims8
A compound of formula I:
- wherein
- R6 is —NR3R4;
- R5 is —(CR═CR—)n(CR═CR2—)R1;
- n is an integer from 0 to 10;
- R1 and R2 are independently selected from the group consisting of —H, —CN, —COOR, CONHR, CON(H)OR, —SO3R, —SO2R—OSO3R, —PO3HR, and —OPO3HR, further wherein at least one of R1 and R2 is not —H;
- each R is independently selected from —H and C1-6 linear or branched alkyl;
- and
- R3 and R4 are independently selected from the group consisting of H, substituted or unsubstituted linear or branched C1-C10 alkyl, substituted or unsubstituted phenyl, substituted or unsubstituted C6-C10 aryl, substituted or unsubstituted C5-C10 heteroaryl, substituted or unsubstituted C5-C10 cycloalkyl, and substituted or unsubstituted C5-C10 heterocycloalkyl;
- or R3 and R4 attached to their N together form a ring that is substituted or unsubstituted C5-C10 heterocycloalkyl, provided that
- if n=0, and R3 and R4 are both:
- (a) H;
- (b) substituted or unsubstituted linear or branched C1-C10 alkyl;
- or (c) substituted or unsubstituted phenyl or C6-C10 aryl, then R1 and R2 are not both selected from the group consisting of —H, —CN, —COOR, —PO3HR, and —CONHR.
10 more elements
Dependencies are inferred from the claim text.