Polycyclic carbogenic molecules and uses thereof as anti-cancer agents
AssigneeNorthwestern University
InventorsRegan James Thomson, Emily E. Robinson
Life of this patent
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Abstract
Disclosed are new polycyclic carbogenic molecules and their methods of synthesis. The new polycyclic carbogenic molecules may be utilized in anti-cancer therapies. In particular, the polycyclic carbogenic molecules may be formulated as pharmaceutical compositions that comprise the small molecules, which compositions may be administered in methods of treating and/or preventing cell proliferative diseases and disorders such as cancer. The new polycyclic carbogenic molecules may be prepared from vinyl- or allyl-substituted cyclohexenone precursors via preparation of a silyl bis-enol ether intermediate.
Claims15
A compound or a salt, solvate, or epoxide, thereof having a Formula I:
- wherein:
- is a single or double bond,
- m and n are selected from 0 or 1;
- and
- each occurrence of R1, R2, R3, R4, R5, R6, R7, and R8 is independently selected from hydrogen, alkyl, hydroxyl, protected hydroxyl, alkoxy, alkoxy-alkyl, and dialkoxy-alkyl;
- or R3 and R5 together form an epoxide and R4 and R6 together from an epoxide;
- or R7 and R8 together from an epoxide.
A compound or a salt, or a solvate thereof having a formula:
- wherein:
- m and n are selected from 0 or 1;
- and
- each occurrence of R1, R2, R3, R4, R5, R6, R7, and R8 is independently selected from hydrogen, alkyl, hydroxyl, protected hydroxyl, alkoxy, alkoxy-alkyl, and dialkoxy-alkyl.
A compound or a salt, solvate, or an epoxide thereof having a formula:
- wherein:
- is a single or double bond,
- each occurrence of R1, R2, R3, R4, R5, R6, R7, and R8 is independently selected from hydrogen, alkyl, hydroxyl, protected hydroxyl, alkoxy, alkoxy-alkyl, and dialkoxy-alkyl;
- or R3 and R5 together form an epoxide;
- or and R4 and R6 together from an epoxide;
- or R7 and R8 together from an epoxide.
A compound having a formula:
A compound having a formula:
A compound having a formula:
A compound having a formula:
Dependencies are inferred from the claim text.