Immunostimulatory compositions and uses therefor
AssigneeBoard of Supervisors of Louisiana State University and Agricultural and Mechanical College
InventorsRonald James Jackson, Charani Ranasinghe
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Abstract
Disclosed are compositions and methods for stimulating immune responses. More particularly, these compositions and methods involve the use of an inhibitor of IL-25 function and an immune stimulator that stimulates an immune response to a target antigen for stimulating protective or therapeutic immune responses to a target antigen. The compositions and methods of the present invention are particularly useful in the prevention and treatment of infections and cancers.
Claims14
An immunostimulatory composition comprising a first agent comprising an immune stimulator or a polynucleotide sequence from which a nucleotide sequence encoding an immune stimulator is expressible, wherein the immune stimulator stimulates or otherwise enhances an immune response to a target antigen in a subject, co-expressed with a second agent comprising an inhibitor of IL-25 function or a polynucleotide from which a nucleotide sequence encoding an inhibitor of IL-25 function is expressible, wherein the first agent comprises a human immunodeficiency virus (HIV) antigen or tuberculosis (TB) antigen, and wherein the second agent comprises IL-25 binding protein.
A kit comprising a priming composition comprising a first agent comprising an immune stimulator or a polynucleotide from which a nucleotide sequence encoding an immune stimulator is expressible, wherein the immune stimulator stimulates or otherwise enhances an immune response to a target antigen in a subject, and a boosting composition comprising the immune stimulator together with a second agent comprising an inhibitor of IL-25 function or a polynucleotide from which a nucleotide sequence encoding an inhibitor of IL-25 function is expressible, wherein the first agent comprises an HIV antigen or TB antigen, and wherein the second agent comprises IL-25 binding protein.
Dependencies are inferred from the claim text.