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US 11,280,795 B2Granted
Quantitative profiling of progesterone metabolites for the prediction of spontaneous preterm delivery
AssigneeIndiana University Research and Technology Corporation
InventorAvinash Shivaputrappa Patil
Life of this patent
Estimating the term…
Abstract
Disclosed are methods for identifying a pregnant female who is susceptible to spontaneous preterm delivery. In particular, disclosed are methods for identifying a pregnant female who is susceptible to spontaneous preterm delivery based on ratios of steroids in samples obtained from the pregnant female.
Claims16
A method of detecting a ratio of deoxycorticosterone (DOC) to 16α-hydroxyprogesterone (16αOHP) in a pregnant female, the method comprising:
- obtaining a sample from the pregnant female;
- detecting a concentration of DOC in the sample;
- detecting a concentration of 16αOHP;
- and
- detecting a ratio of DOC/16αOHP.
2 more elements
A method for identifying a pregnant female as being susceptible to spontaneous preterm delivery, the method comprising:
- obtaining a sample from the pregnant female;
- determining a concentration of a first steroid selected from the group consisting of deoxycorticosterone, corticosterone, 18-hydroxycorticosterone, aldosterone, deoxycortisol, cortisol and combinations thereof in the sample;
- determining a concentration of at least a second steroid, wherein the second steroid is different from the first steroid;
- calculating a ratio of the first steroid and the at least second steroid;
- and
- identifying the pregnant female as being susceptible to spontaneous preterm delivery when the ratio in the sample is reduced below a threshold value.
3 more elements
Dependencies are inferred from the claim text.