Encapsulated pre-analytic workflows for flow-through devices, liquid chromatography and mass spectrometric analysis
AssigneeWaters Technologies Corporation
InventorsKevin Daniel Wyndham, Darryl W. Brousmiche
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Abstract
This invention relates to encapsulated workflow reagents comprising an encapsulating material and a workflow reagent encapsulated within the encapsulating material for sample and workflow preparation prior to chromatographic, spectroscopic or other analytical systems, use thereof, and devices comprising the same.
Claims18
An encapsulated workflow reagent comprising an encapsulating material and a workflow reagent encapsulated within the encapsulating material, wherein the workflow reagent encapsulated within the encapsulating material is attached to a surface of a scaffolding material, wherein the scaffolding material is a porous solid, wherein the workflow reagent is an enzyme, and wherein the encapsulating material is made with one or more polymers configured to provide a controlled release of the workflow reagent, wherein the encapsulating material is covalently attached to a surface of the scaffolding material and wherein the encapsulated workflow reagent material has the formula [(B)—(Y)n)]o˜EM (Formula I), where
- EM represents the encapsulating material;
- B represents a-the scaffolding material;
- Y is a linker group between the encapsulating material and a surface of the scaffolding material;
- o is an integer greater than 0;
- and
- n is an integer greater than or equal to 1.
Dependencies are inferred from the claim text.