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US 11,279,966 B2Granted
Method for identifying compound for inhibiting an activity of a histone lysine demethylase
AssigneeNational Tsing Hua University
InventorsWen-Ching Wang, Hsing-Jien Kung, Chia-Han Chu, Jing-Moon Yang
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Abstract
A method for identifying a compound that inhibits an activity of a histone lysine demethylase, in which the compound interacts with three sites of a pocket of the histone lysine demethylase generated by using a computer program, an alpha-ketoglutarate (AKG), a methylated lysine, and a NIQ.
Claims5
A method for identifying a compound which inhibits an activity of a histone lysine demethylase, comprising:
- (a) using a computer program to generate a three-dimensional structure of a pocket of the histone lysine demethylase, wherein the pocket comprises three sites:
- an alpha-ketoglutarate (AKG), a methylated lysine, and a NIQ;
- (b) screening for a compound that interacts with the three sites of said pocket;
- and
- (c) testing the compound screened in (b) by in vitro or in vivo assay for its ability to inhibit the activity of the histone lysine demethylase, thereby identifying a compound that inhibits the activity of the histone lysine demethylase.
2 more elements
Dependencies are inferred from the claim text.