Adenoviral vector encoding human atonal homolog-1 (HATH1)
AssigneeGenVec, Inc.
InventorsDouglas E. Brough, Damodar R. Ettyreddy
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Abstract
The invention is directed to a replication-deficient adenoviral vector comprising a nucleic acid sequence encoding a human atonal homolog-1 (Hath1) protein operably linked to a human glial fibrillary acidic protein (GFAP) promoter. The invention also is directed to a composition and method utilizing the adenoviral vector to generate sensory cells in the inner ear of a human.
Claims8
A method of generating sensory cells in the inner ear of a human in need thereof, which method comprises administering to the inner ear of the human a composition comprising an adenoviral vector and a pharmaceutically acceptable carrier, wherein the adenoviral vector comprises a nucleic acid sequence comprising SEQ ID NO:
- 3, wherein SEQ ID NO:
- 3 comprises the nucleic acid sequence of SEQ ID NO:
- 1 encoding human atonal homolog-1 (Hath1) protein and whereupon SEQ ID NO:
- 1 is expressed and sensory cells in the inner ear are generated.
A method of generating sensory cells in the inner ear of a human in need thereof, which method comprises administering to the inner ear of the human a composition comprising an adenoviral vector and a pharmaceutically acceptable carrier, wherein the adenoviral vector comprises a nucleic acid sequence consisting of SEQ ID NO:
- 3, wherein SEQ ID NO:
- 3 comprises the nucleic acid sequence of SEQ ID NO:
- 1 encoding human atonal homolog-1(Hath1) protein and whereupon SEQ ID NO:
- 1 is expressed and sensory cells in the inner ear are generated.
Dependencies are inferred from the claim text.