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US 11,279,916 B2Granted
Enzyme and application thereof
AssigneeShanghai Jiao Tong University
InventorsPing Xu, Hongzhi Tang, Kunzhi Zhang, Geng Wu, Fei Tao
Life of this patent
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Abstract
Provides an artificial enzyme obtained by improving upon a sequence of a natural nicotine dehydrogenase, wherein the improvement comprises replacing at least one amino acid hindering product release with an amino acid with smaller side chains, thereby improving a catalytic rate.
Claims1
An enzyme, the enzyme having the activity for catalyzing the conversion reaction from compound I to compound II as shown by the following formula:
- wherein the enzyme has an amino acid sequence as shown in SEQ ID NO:2, or as shown in SEQ ID NO:8, or as shown in SEQ ID NO:9, or as shown in SEQ ID NO:10, or as shown in SEQ ID NO:11.
Dependencies are inferred from the claim text.