Anti-Sialyl Tn chimeric antigen receptors

A chimeric antigen receptor (CAR) comprising:

• an extracellular domain that comprises:
• a) an anti-sialyl Tn (STn) antibody or antigen binding fragment thereof that binds one or more epitopes of an STn antigen expressed on a glycoprotein, wherein the anti-STn antibody or antigen binding fragment thereof comprises a variable light chain sequence comprising CDRL1-CDRL3 sequences set forth in SEQ ID NOs:
• 9-11, and a variable heavy chain sequence comprising CDRH1-CDRH3 sequences set forth in SEQ ID NOs:
• 12-14, wherein the variable light chain comprises SEQ ID NO:
• 15 or 23 and the variable heavy chain comprises SEQ ID NO:
• 16 or 24;
• b) a transmembrane domain;
• c) one or more intracellular co-stimulatory signaling domains;
• and
• d) a primary signaling domain.