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US 11,279,731 B2Granted
Ligand functional substrates
Assignee3M Innovative Properties Company
InventorsJerald K. Rasmussen, Catherine A. Bothof, Kannan Seshadri, James I. Hembre, Robert T. Fitzsimons, Jr., George W. Griesgraber, Yi He
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Abstract
A substrate comprising a crosslinked polymer primer layer, and grafted thereto a ligand-functionalized polymer is provided. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, and proteins, at pH's near or below the pI's of the biomaterials.
Claims18
A ligand functional substrate comprising:
- a) a substrate, and
- b) a crosslinked ligand-functional alkenyl (co)polymer layer coated on the surface of the substrate, wherein the ligand-functional alkenyl (co)polymer comprises polymerized monomer units of the formula:
- wherein
- R1 is H or C1-C4 alkyl;
- R2 is a divalent alkylene having 1 to 20 carbon atoms;
- each R3 is independently H or C1-C4 alkyl;
- R4 is H, C1-C4 alkyl or —N(R3)2;
- R5 is H or C1-C4 alkyl or aryl;
- X1 is —O— or —NR3—,
- o is 0 or 1, and
- n is 1 or 2.
8 more elements
Dependencies are inferred from the claim text.