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US 11,274,119 B2Granted
Industrial process for the synthesis of nomegestrol-acetate
AssigneeRichter Gedeon Nyrt.
InventorsSándor Mahó, János Csörgei, Csaba Sánta, Péter Vincze, László Balogh, János Horváth, Zoltán Béni
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Abstract
The invention relates to the last step of a synthetic process, in which Nomegestrol-acetate of formula (I) is synthesized from 17α-acetoxy-6-methylene-19-norpregn-4-ene-3,20-dione of formula (II) in the presence of Pd/C catalyst and acetic acid in hot ethanolic solution.
Claims7
A process for the synthesis of Nomegestrol-acetate of formula (I)
- characterized by
- adding the solid starting steroid of formula (II)
- into an ethanolic solution at 50-78° C., which contains 0.05-0.2 mass fraction of 10% Pd/C catalyst, and 0.01-0.2 mass fraction of acetic acid calculated on the weight of the starting steroid of formula (II), then, after 3-15 min reaction time the catalyst is filtered off, the filtrate is concentrated to one fourth in vacuum, water is added to residue and the precipitated product of formula (I) is filtered off at 0-25° C.
Dependencies are inferred from the claim text.