EP300/CREBBP inhibitor

A compound represented by formula (1) or a pharmacologically acceptable salt thereof:

• wherein ring Q1 represents a phenyl group optionally having 1 to 3 substituents independently selected from group A;
• ring Q2 represents an 8-membered to 10-membered bicyclic aromatic heterocyclic group optionally having, in a ring, 1 to 4 hetero atoms independently selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom (wherein the 8-membered to 10-membered bicyclic aromatic heterocyclic group optionally has 1 to 3 substituents independently selected from group B);
• R1 and R2 each independently represent a C1-6 alkyl group or a C1-6 alkoxy group, or
• R1 and R2 form, together with a carbon atom to which R1 and R2 are bonded, a 3-membered to 7-membered cycloalkyl ring optionally having 1 to 3 substituents independently selected from group C, a tetrahydropyran ring optionally having 1 to 3 substituents independently selected from group C, or a dioxane ring optionally having 1 to 3 substituents independently selected from group C;
• and
• R3 and R4 form, together with a nitrogen atom to which R3 is bonded and a carbon atom to which R4 is bonded, an azetidine ring optionally having 1 to 3 substituents independently selected from group D, a pyrrolidine ring optionally having 1 to 3 substituents independently selected from group D, a hexamethyleneimine ring optionally having 1 to 3 substituents independently selected from group D, a thiazolidine ring optionally having 1 to 3 substituents independently selected from group D, a 1-oxothiazolidine ring optionally having 1 to 3 substituents independently selected from group D, a 1,1-dioxothiazolidine ring optionally having 1 to 3 substituents independently selected from group D, or a 4-oxopyrrolidine ring optionally having 1 to 3 substituents independently selected from group D:
• Group A:
• a halogen atom, a hydroxy group, a carboxy group, a C1-6 alkyl group, a hydroxy C1-6 alkyl group, a C1-6 alkoxy group, a halo C1-6 alkoxy group, a C1-6 alkoxycarbonyl group, a C2-7 alkanoyl group, a halo C2-7 alkanoyl group, a C2-7 alkanoylamino group, a C1-6 alkylsulfonyl group, a C1-6 alkylsulfonylamino group, a C3-7 cycloalkylsulfonylamino group, a phenyl group, a phenylsulfonylamino group, a carbamoyl group, a C1-6 alkylcarbamoyl group, a di-C1-6 alkylcarbamoyl group, a benzyloxycarbonyl group, a C3-7 cycloalkylsulfonylcarbamoyl group, a halo C1-6 alkylsulfonyloxy group and a phenyl sulfonyl group,
• Group B:
• a halogen atom, a cyano group, an amino group, a C1-6 alkyl group, a C1-6 alkoxy group, a hydroxy C1-6 alkyl group, a C1-6 alkylamino group, a C1-6 alkylamino C1-6 alkyl group, a morpholinyl C1-6 alkyloxy group, a phenyl group, a benzyloxy group, a C1-6 alkoxy C1-6 alkyl group, a hydroxy group, a halo C1-6 alkyl group, a C1-6 alkoxycarbonyl group, a C2-7 alkanoylamino group, a halo C1-6 alkoxy group, a C1-6 alkoxy C1-6 alkoxy group, a C1-6 alkylsulfonylamino group, a morpholinyl C1-6 alkyl group and a C1-6 alkylsulfonyl group,
• Group C:
• a halogen atom, a C1-6 alkyl group and a C1-6 alkoxy group, and
• Group D:
• a halogen atom, a hydroxy group, a C1-6 alkyl group, a C1-6 alkoxy group, a C1-6 alkoxy C1-6 alkoxy group, a C2-6 alkynyl group, a C2-7 alkanoylamino group, an amino group and a di-C1-6 alkylamino group.