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US 11,273,208 B2Granted
CAMKK1 as a novel regenerative therapeutic
AssigneesSumma Health, Northeast Ohio Medical University
InventorsMarc S. Penn, Matthew Kiedrowski, Maritza Mayorga
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Abstract
Disclosed herein are methods of treating an ischemic or inflammatory condition in an organ or tissue of a patient comprising inducing an increase of the level of CAMKK1 in said organ or tissue.
Claims14
A method of preventing fibrosis or increasing vascular density in an organ or tissue of a patient, the method comprising administering to the patient:
- (a) cells comprising:
- a vector comprising a nucleic acid encoding human calcium/calmodulin-dependent protein kinase kinase 1 (CAMKK1) selected from the group of:
- the protein of SEQ ID NO:
- 4, the T108A mutant CAMKK1, the S459A mutant CAMKK1, or the T108A/S459A mutant CAMKK1, wherein T108 corresponds to position 108 of SEQ ID NO:
- 2 and S459 corresponds to position 458 of SEQ ID NO:
- 2, to said organ or tissue, and optionally wherein the vector is a plasmid or a viral vector;
- or
- (b) conditioned media from a culture of the cells of (a) that have been modified to have an increase of the level of human CAMKK1 protein to said organ or tissue, thereby preventing fibrosis or increasing vascular density in the organ or tissue of the patient.
5 more elements
A method of preventing fibrosis or increasing vascular density in an organ or tissue of a patient by modulating a secretome expression of a cell in said organ or tissue by human CAMKK1, the method comprising:
- administering a vector comprising a nucleic acid encoding human calcium/calmodulin-dependent protein kinase kinase 1 (CAMKK1) selected from the group of:
- the protein of SEQ ID NO:
- 4, the T108A mutant CAMKKI, the S459A mutant CAMKK, or the T108A/S459A mutant CAMKKI, wherein T108 corresponds to position 108 of SEQ ID NO:
- 2 and S459 corresponds to position 458 of SEQ ID NO:
- 2, to a cell of said organ or tissue thereby inducing an increased level of human CAMKK1 in the cell, and optionally wherein the vector is a plasmid or a viral vector,
- thereby modulating a secretome expression of the cell by the human CAMKK1 to prevent fibrosis or increase vascular density in the organ or tissue in the patient.
3 more elements
Dependencies are inferred from the claim text.