Methods of mitigating toxic effects of vesicants and caustic gas
AssigneesJanssen Pharmaceutica NV, Rutgers, The State University of New Jersey
InventorsGary Eichenbaum, Edward John Yurkow
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Abstract
Methods and kits for mitigating a toxic effect of at least one of vesicants and caustic gases in a subject in need thereof are described. In particular, an effective amount of a thrombopoietin (TPO) mimetic, such as RWJ-800088 or romiplostim, is used to mitigate the toxic effect of the vesicant or caustic gas.
Claims18
A method of mitigating a toxic effect of at least one of a vesicant and a caustic gas in a subject in need thereof, the method comprising administering to the subject an effective amount of a thrombopoietin (TPO) mimetic comprising the amino acid sequence of SEQ ID NO:1,
- wherein the toxic effect induced by the at least one of the vesicant and the caustic gas is selected from the group consisting of pulmonary vascular damage, pulmonary hemorrhage, pulmonary fibrosis, pulmonary cellular influx, and mortality,
- and wherein the vesicant is selected from the group consisting of distilled mustard, mustard gas, lewisite, mustard/lewisite, mustard/T, nitrogen mustard, sesqui mustard, sulfur mustard, phosgene oxime, cantharidin, and furanocoumarin.
A method of mitigating a toxic effect of nitrogen mustard in a subject in need thereof, the method comprising administering to the subject an effective amount of a thrombopoietin (TPO) mimetic comprising the amino acid sequence of SEQ ID NO:1,
- wherein the toxic effect induced by the nitrogen mustard is selected from the group consisting of pulmonary vascular damage, pulmonary hemorrhage, pulmonary fibrosis, and pulmonary cellular influx.
Dependencies are inferred from the claim text.