Compound for modulating DDAH and ADMA levels, as well as methods of using thereof to treat disease

A method for modulating DDAH and asymmetric dimethylarginine (ADMA) in a subject, the method comprising administering to the subject a composition comprising a therapeutically effective amount of a compound defined by Formula I:

• or a pharmaceutically acceptable salt or prodrug thereof, wherein
• represents a single, double, or triple bond;
• X1 and X2, as valence permits, are independently absent with one of X1 and X2, being selected from C, CH, CH2, O, CO, S, SO2, and NR′ or both X1 and X2, as valence permits, are independently selected from C, CH, CH2, O, CO, S, SO2, and NR′;
• wherein R′ is independently selected from hydrogen or C1-C6 alkyl;
• or X1 and X2 together with the bond to which they are attached form a 3 or 4 membered carbocyclic ring;
• R2 is, independently for each occurrence, selected from halogen, cyano, hydroxyl, amino, alkylamino, dialkylamino, alkyl, haloalkyl;
• alkylthio;
• haloalkylthio;
• alkoxy, haloalkoxy, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, alkylcarbonyl, haloalkylcarbonyl, alkoxy carbonyl, haloalkoxy carbonyl, alkylaminocarbonyl, heteroalkylaminocarbonyl, dialkylaminocarbonyl, and heterodialkylaminocarbonyl;
• n is an integer from 0 to 4;
• Y is selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each optionally substituted with one or more substituents individually selected from R″;
• and
• R″ is, independently for each occurrence, selected from fluoro, cyano, nitro, hydroxyl, amino, alkylamino, dialkylamino, nitrile, alkyl, haloalkyl;
• alkylthio;
• haloalkylthio;
• alkoxy, haloalkoxy, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, alkylcarbonyl, haloalkylcarbonyl, alkoxy carbonyl, haloalkoxy carbonyl, alkylaminocarbonyl, heteroalkylaminocarbonyl, dialkylaminocarbonyl, and heterodialkylaminocarbonyl, with the proviso that when R″ is hydroxyl, Y further comprises a second substituent.