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US 11,266,742 B2Granted
Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates
AssigneeNektar Therapeutics
InventorsMichael D. Bentley, Sean M. Culbertson, Samuel P. McManus
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Abstract
The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. The conjugates as well as the polymeric reagents used to form the conjugates include at least one of each the following: an aromatic moiety comprising an ionizable hydrogen atom, a spacer moiety, and a water-soluble polymer. Methods of making polymeric reagents and conjugates, as well as methods for administering conjugates and compositions, are also provided.
Claims11
A conjugate having a structure:
- wherein each m-PEG is a methoxy poly(ethylene glycol), and
- Drug is a residue of a biologically active agent comprising an amino group.
A polymeric reagent of a structure:
- wherein each m-PEG is a methoxy poly(ethylene glycol), and
- (FG) is a functional group capable of reacting with an amino group of a biologically active agent.
Dependencies are inferred from the claim text.