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US 11,261,274 B2Granted
Polymer particles
AssigneeTerumo Kabushiki Kaisha
InventorsSteve Plotkin, Gregory M. Cruise, Edward Michael Keeley, Renee Yu, Clayton Harris
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Abstract
Polymer particle embolics and methods of making same are described. The particle embolics can be used as embolization agents.
Claims20
A polymer particle comprising:
- a poly(ethylene glycol) diacrylamide macromer;
- a first monomer;
- and
- a second monomer configured to allow binding of positively charged drugs, wherein the second monomer is selected from acrylic acid, 3-sulfopropyl acrylate, 3-sulfopropyl methacrylate, a salt thereof, or a combination thereof;
- wherein the polymer particle is spherical.
2 more elements
A polymer particle comprising:
- a poly(ethylene glycol) macromer,
- a first monomer;
- and
- a second monomer configured allow binding of negatively charged drugs, wherein the second monomer is selected from amino ethyl methacrylate, 2-amino ethyl methacrylate, amino propyl methacrylamide, a salt thereof, or a combination thereof;
- wherein the polymer particle is spherical.
2 more elements
A kit comprising:
- a plurality of polymer particles in a container,
- wherein the plurality of polymer particles comprise a reaction product of:
- a poly(ethylene glycol) diacrylamide macromer;
- a first monomer;
- and
- a second monomer configured to allow binding of positively charged drugs,
- wherein the second monomer is selected from acrylic acid, methacrylic acid, 3-sulfopropyl acrylate, 3-sulfopropyl methacrylate, a salt thereof, or a combination thereof;
- wherein the plurality of polymer particles are spherical and have a diameter less than about 1,200 μm.
5 more elements
A kit comprising:
- a plurality of polymer particles in a container,
- wherein the plurality of polymer particles comprise a reaction product of:
- a poly(ethylene glycol) macromer;
- a first monomer;
- and
- a second monomer configured allow binding of negatively charged drugs, wherein the second monomer is selected from amino ethyl methacrylate, 2-amino ethyl methacrylate, amino propyl methacrylamide, a salt thereof, or a combination thereof;
- wherein the plurality of polymer particles are spherical and have a diameter less than about 1,200 μm.
4 more elements
Dependencies are inferred from the claim text.