Activators of autophagic flux and phospholipase d and clearance of protein aggregates including tau and treatment of proteinopathies
AssigneesThe Trustees of Columbia University in the City of New York, NY State Psychiatric Institute
InventorsKirsten Alison Rinderspacher, Wai Yu, Karen Duff, Donald Landry, Shi-Xian Deng
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Abstract
The present application discloses compounds which are activators of autophagic flux and pharmaceutical compositions comprising said activators. It further discloses use of said compounds and pharmaceutical compositions in the treatment of neurodegenerative diseases, particularly proteinopathies and tauopathies such as Alzheimer's disease. It further discloses methods of enhancing autophagic flux.
Claims14
A compound selected from:
- or a pharmaceutically acceptable salt, enantiomer, racemate, mixture thereof, or combination thereof.
A method of treating a neurodegenerative disease comprising administering to a subject in need thereof an effective amount of a compound having the following structure:
- or a pharmaceutical composition thereof.
A method of enhancing autophagic reflux comprising providing to a cell or a protein aggregate an effective amount of a compound having the following structure:
- or a pharmaceutical composition thereof.
A method of treating a proteinopathy comprising administering to a subject in need thereof an effective amount of a compound having the following structure:
- or a pharmaceutical composition thereof.
A method of treating a tauopathy comprising administering to a subject in need thereof an effective amount of a compound having the following structure:
- or a pharmaceutical composition thereof.
Dependencies are inferred from the claim text.