System and process for purification of astatine-211 from target materials
AssigneeBattelle Memorial Institute
InventorMatthew J. O'Hara
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Abstract
A new column-based purification system and approach are described for rapid separation and purification of the alpha-emitting therapeutic radioisotope 211At from dissolved cyclotron targets that provide highly reproducible product results with excellent 211At species distributions and high antibody labeling yields compared with prior art manual extraction results of the prior art that can be expected to enable enhanced production of purified 211At isotope products suitable for therapeutic medical applications such as treatment of cancer in human patients.
Claims10
A method for producing a purified 211At isotope product from dissolved cyclotron targets, the method comprising:
- dissolving a cyclotron target containing 211At and Bi in a nitric acid solution to form a first solution comprising 211At and Bi-nitrate salts;
- removing the liquid from the first solution to form a first composition comprising 211At and Bi-nitrate salts;
- dissolving the first composition in an HCl solution to form a second solution comprising the 211At and Bi in an HCl solution;
- preparing a separation media with conditioning solution comprising HCl to acidify the separation media;
- passing the second solution through the separation media to associate 211At isotopes with the media and recover Bi as an eluent;
- and
- passing an At elution solution comprising HNO3 through the separation media to elute 211At isotopes from the separation media and provide 211At isotopes in an HNO3 solution.
Dependencies are inferred from the claim text.