Agrobacterium derived cell penetrating peptides as nanocarriers
AssigneeIndian Institute of Technology Delhi
InventorsArchana Chugh, Aastha Jain, Mudit Mishra
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Abstract
The present invention relates to a nanocarrier peptide sequence (SEQ ID NO: 6 KXPXXXXA/V/GXGNXX; wherein X is selected from amino acid R, K, A or H. The present invention also relates to the method for cellular delivery, by implementing the steps of: complexation of a peptide nanocarrier sequence: KXPXXXXA/V/GXGNXX; where X is selected from amino acid R,K,A and H having SEQ ID NO: 6 with a macromolecule to obtain a complex; and administering the complex to a targeted mammalian or plant cell or tissue.
Claims8
A peptide nanocarrier sequence selected from the group consisting of SEQ ID NO:
- 3, SEQ ID NO:
- 4 and SEQ ID NO:
- 5.
A method for cellular delivery, comprising the steps of:
- a) complexation of a peptide nanocarrier sequence selected from the group
- consisting of SEQ ID NO:
- 3, SEQ ID NO:
- 4 and SEQ ID NO:
- 5 with a macromolecule to obtain a complex;
- b) administering the complex in the concentration range of 0.1 uM to 50 uM to a targeted mammalian or plant cell or tissue at predetermined pH and temperature conditions.
The method as according to 6, wherein said macromolecule is selected from a group comprising of a peptide, a polypeptide, or a protein, a polysaccharide, a lipid, a lipoprotein, a glyco lipid, a nucleic acid, a small drug molecule or a toxin, a nanoparticle and an imaging or contrast agent.
Dependencies are inferred from the claim text.