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US 11,254,924 B2Granted
Method for biocatalysis using filamentous fungi
AssigneeThe University of the West Indies
InventorsPaul B. Reese, Patrice Peart, Avril R. M. Chen-Collins
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Abstract
A method is disclosed in which filamentous fungi are macerated and encapsulated in an inert matrix to form beads, which can be used to promote reactions carried out by the fungi. The beads are useful, e.g., for producing compounds and compound libraries.
Claims9
A method of producing a library of bioconversion compounds, the method comprising
- providing a first fungal bead containing a grown first fungal species;
- providing a second fungal bead containing a grown second fungal species;
- combining the first and second fungal beads, a medium free of nutrients that promote fungal growth, and a compound in a single vessel to form an incubation mixture, wherein the first and second fungal species are not growing and are not in contact with each other;
- incubating the incubation mixture to produce a library comprising multiple bioconversion compounds;
- and
- isolating a mixture of the multiple bioconversion compounds and screening the isolated mixture of the multiple bioconversion compounds for biological activity without isolating the individual bioconversion compounds.
3 more elements
Dependencies are inferred from the claim text.