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US 11,254,912 B2Granted
Methods and compositions for treating cancer
AssigneeCrispr Therapeutics AG
InventorsJonathan Alexander Terrett, Demetrios Kalaitzidis, Mary-Lee Dequéant, Zinkal Samir Padalia
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Abstract
Provided herein, in some embodiments, are methods and compositions (e.g., cell compositions) for the treatment of cancer. The methods and compositions involve genetically engineered immune cells (e.g., T cells), in which the endogenous CD70 gene is disrupted by genetic editing, for example, the CRISPR/Cas9 gene editing technology.
Claims14
A population of engineered T cells, wherein the engineered T cells comprise:
- (i) a disrupted TRAC gene;
- (ii) a disrupted fI2M gene;
- (iii) a disrupted CD70 gene;
- and
- (iv) a nucleic acid encoding a CAR that binds CD70;
- wherein the CAR that binds CD70 comprises the amino acid sequence of SEO ID NO:
- 46.
4 more elements
Dependencies are inferred from the claim text.