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US 11,254,739 B2Granted
Anti-human migration stimulating factor (MSF) and uses thereof
AssigneeHumanitas Mirasole S.P.A.
InventorsAlberto Mantovani, Barbara Bottazzi, Ilaria Laface, Antonio Inforzato, Tamara Gulic
Life of this patent
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Abstract
The present invention refers to an antibody able to recognize and bind to an epitope comprised in a sequence of human Migration Stimulating Factor (MSF), and that doesn't recognize and bind human Fibronectin 1 (hFn1) and to uses in diagnostic methods and therapy.
Claims16
An antibody that comprises:
- a complementarity determining region 3 of the heavy chain (CDRH3) having the amino acid sequence WDY SEQ ID No:
- 12;
- and
- a complementarity determining region 2 of the heavy chain (CDRH2) having the amino acid sequence EIRMKSDNYATYYAESVKG (SEQ ID NO:13);
- and
- a complementarity determining region 1 of the heavy chain (CDRH1) having the amino acid sequence NDWMN (SEQ ID NO:14);
- and
- a complementarity determining region 3 of the light chain (CDRL3) having the amino acid sequence KQSYNLHT (SEQ ID NO:15);
- and
- a complementarity determining region 2 of the light chain (CDRL2) having the amino acid sequence WASTRYS (SEQ ID NO:16);
- and
- a complementarity determining region 1 of the light chain (CDRL1) having the amino acid sequence RSSHYLLNSRTRKNFLS (SEQ ID NO:17).
9 more elements
Dependencies are inferred from the claim text.