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AssigneesThe United States of America, as represented by the Secretary, Depar tment of Health and Human Services, Washington University
InventorsJeffrey S. Isenberg, David D. Roberts, William A. Frazier
Estimating the term…
Provided herein are compositions for preventing, ameliorating, and/or reducing tissue ischemia and/or tissue damage due to ischemia, increasing blood vessel diameter, blood flow and tissue perfusion in the presence of vascular disease including peripheral vascular disease, atherosclerotic vascular disease, coronary artery disease, stroke and influencing other conditions, by suppressing CD47 and/or blocking TSP1 and/or CD47 activity or interaction. Influencing the interaction of CD47-TSP1 in blood vessels allows for control of blood vessel diameter and blood flow, and permits modification of blood pressure and cardiac function. Under conditions of decreased blood flow, for instance through injury or atherosclerosis, blocking TSP1-CD47 interaction allows blood vessels to dilate and increases blood flow, tissue perfusion and tissue survival.
An isolated or synthetic peptide having specific binding affinity for CD47, consisting of 8 to 10 amino acids in length, and comprising of the sequence R1—X1—X2—X3-Lys-X4—X5—X6—X7—X8-Arg-X9—R2, wherein:
Dependencies are inferred from the claim text.